| 
| | Newsletter Vol.
5, No. 1, Spring 2007 | | In
this issue | | A word from our president:
How NOT to do a Customer Survey
|
|
| |
Several
weeks ago we sent out a customer survey by e-mail with the purpose
of gaining a better understanding of the needs of our customers as
well as determining how we could improve overall customer
satisfaction. We like to think of ourselves as partners with our
customers, and as the needs and workflow issues change within our
different markets we want to continue to change our organization to
provide better products and services.
The marketing firm we engaged to help us with this
project insisted that the e-mail come directly from me so customers
would take it seriously. Unfortunately they didn't do a very good
job of translating our database and quite a few customers were
addressed by the wrong first name. Some thought it was funny; some
didn't. At least one person thought we were questioning their
gender!
"Dear Paul, Joe and anyone who knows me in
Texas!!
Just got this—may try it later, despite the fact you got my first
name wrong—something that *might* annoy some people—luckily I'm
all sweetness and light!"
"If you can't get my name right as a customer I
am not sure how objective I would be on answering a customer survey.
If you would like to resend with something a little closer to my
name I probably would be in a better frame of mind."
"Although I am Irish, my name is John...and to
the best of my knowledge I have not undergone a sex change
operation."
Oh well, I can ensure you that our intentions were
good. Just to show I have a sense of humor I will include my photo
with my head in a Mona Lisa cutout. To the best of my knowledge I
also have not undergone a sex change operation.
Paul N. Swepston
|
Calendar of
events | |
Rigaku
at ACA 2007
|
|
Rigaku will be attending the following conferences in
the coming months:
- South
West Structural Biology Consortium, Portsmouth, UK, June
18-19
- Second
North America-Greece-Cyprus Workshop on Paramagnetic Materials,
Syros, Greece, June 18-21
- ACA,
Salt Lake City, UT, July 21-26
- DXC,
Colorado Springs, CO, July 30-August 3
- 2nd
Annual Structural Biology and Molecular Biophysics Workshop,
Omaha, NE, August 6
- ACS,
Boston, MA, August 19-23
- ECM,
Marrakech, Morocco, August 22-27
Full listing of conferences
Rigaku will attend in 2007
| |
Drop by booth #303 at the 2007 meeting
of the American Crystallographic Association in Salt Lake
City on July 21-25 to see what Rigaku has on display. We will be
demonstrating automation products (Alchemist™ II,
BirdFeeder™, Desktop Minstrel™,
Gallery™ 160 Plate Hotel, ACTOR™ accessories), X-ray generators
(MicroMax™-002+,
FR-E+ SuperBright™), detectors
(SCXmini™,
R-AXIS IV++,
Saturn A200), X-ray optics and
accessories such as the
Free
Mounting™ System.
Rigaku employees will also be available to conduct
software demos, including MIFit.
On the first
day of the exhibition, Sunday, July 22, Rigaku will hold a
luncheon at noon at the convention center that will feature
presentations by Vick Nienaber from ActiveSight ("Turning structures into leads through
fragment-based screening)
and Joe Ferrara: ("Homelabs vs. Synchrotrons: The Truth Will
Surprise You").
Our annual Fun Run will
be held on Monday morning at 7:00 at Memory Grove Park.
Rigaku employees are involved in the
following presentations or posters during the conference:
| Date |
Time |
Authors |
Title |
Presentation |
| Sunday, July 22 |
Poster
|
Joseph D. Ferrara, Lee M.
Daniels, Hugh Garvey, James W. Pflugrath, Katsunari Sasaki,
Cheng Yang, |
Recent Advances in IP and CCD
Technology |
MP234 (W0216) |
| 09:00—09:20 |
Carrie Wilmot, Arwen Pearson,
Bradley Elmore, Cheng Yang, Joseph Ferrara, Alan Hooper |
The
Crystal Structure of Cytochrome P460 of Nitrosomonas europaea
Reveals a Novel Cytochrome Fold and Heme-protein Cross-link |
01.01.02
(W0007) |
| 04:10—04:30 |
Lee M. Daniels, T. Stanley
Cameron, Joseph D. Ferrara |
Non-traditional Bonding Interactions via Experimental Charge
Density |
10.01.14 (W0347) |
|
Poster
|
Jian Xu, Matt Lundy, Michael
Willis |
Automated Liquid Dispensing with Precision and Accuracy for
Protein Crystallization Using the Alchemist II |
SP073 (W0401) |
| Monday, July 23 |
09:40—10:00 |
Cheng Yang, James W. Pflugrath,
Joseph D. Ferrara |
Taking the Edge Off: The Softer Side of In-house SAD
Phasing |
01.03.04 (W0325) |
| 10.30—10.50 |
J.Badger, P.Collins,
R.Rosenfeld, B.Smith, R.Athay, D.E.McRee, |
From Images to Co-crystal Structures in a Single Automated
Process |
04.01.06 (W0002) |
| Poster |
Kris F. Tesh, A. L. Dowell,
Joseph D. Ferrara, J.W. Pflugrath |
Trash to Treasure: Changing a Poorly Diffracting Frozen Crystal
to a High Resolution Data Set |
MP082 (W0258) |
| Robin Rosenfeld, John Badger,
Paul Collins, Vicki Nienabar, Duncan McRee |
Structure Based Fragment Screening: Finding Hits for
Novel Lead Compound Design
|
MP178 (W0369)
|
|
Wednesday, July 25 |
Poster |
Ronald E. Benson |
The Bench Top X-ray Diffractometer as an Effective Teaching
Tool |
MP241 (W0410) |
We hope to see you in Salt Lake City!
>>> Visit the
ACA 2007
website
|
|
Introducing:
ACTOR™ SM |
|
ACTOR
SM
is
the
world's
first
commercial
robotic
system
for
automated
handling
of
crystals
for
small
molecule
structure
determination.
The
system,
offering
fully
automated
sample
handling
of
up
to
60
crystals,
provides
automatic
crystal
transport,
centering,
and
retrieval,
offering
the
user
complete
lights-out
operation.
ACTOR
SM
will
let
you
perform
more
experiments
and
produce
more
structures.
When
coupled
with
Rigaku
diffractometers
and
Rigaku's
turnkey
automated
structure
solution
software,
ACTOR
SM
offers
fully
automated
crystal
screening
and
complete
structure
solution
capabilities.
>>>
Click here for more information
|
| What's
in a name? | |
Rigaku
at DXC 2007
| |
"Rigaku" is a name and not actually a word, but it means something like "learning
science."Aya Takase of Rigaku Corporation explains: "RI" of Rigaku means
science or logic, and is used in words like "ri-ka"
(science), "ri-yu" (reason), "ri-kutsu"
(logic), and "ri-ron" (theory).
"GAKU" of Rigaku is analogous to the English suffix
"-ology," meaning study or learning. It is used in words like
"gak-kou" (school), "gaku-mon" (learning, scholarship,
wisdom), and "gaku-jutsu-teki" (academic).
"Rigaku" was originally spelled in Kanji (Chinese characters)
and is written like this:
>>>
Click here for more information
| |
This year Rigaku will again prove that there truly is a small solution to many
of your big problems. Come by the booth (#45) and see the new WDXRF Primini®. Your
benchtop has never been more powerful, your job has never been so easy, your
budget has never felt more at ease. We will also be demonstrating
the SCXmini
benchtop single crystal diffractometer, the MicroMax-002+
microfocus sealed tube generator and X-ray optics. Rigaku will be hosting a free lunch time seminar on Tuesday, July 31 at 12:30.
Invitations can be picked up at the Rigaku booth during exhibition hours
all day Monday and Tuesday morning.
We are also sponsoring two technical
sessions: "Diffraction from Biopolymers and
Biological systems" and "Polymers and Composites."
Rigaku employees will be making the
following presentations during the conference:
|
|
Reciprocal space mapping of epitaxial
nanowires |
J. Li, A. Tripathi, L.
Fields, T. McNulty, D. Stokes, K. Bassler, S. Moss |
|
| D-7
|
Trace Phase Analysis Using The Calibration Curve Method Under Various
Conditions
|
E. Kagami, A. Takase
|
|
|
D-66 |
The
Evaluation Of Preferential Alignment Of Biological Apatite (Bap) Crystallites In Bone Using Transmission X-Ray
Diffraction Method |
Katsunari Sasaki, Takayoshi
Nakano, Yukichi Umakoshi and Toshihiko Sasaki |
|
|
D-67 |
The
Development Of Two Color Multi Layer Mirror System And Its
Application For Micro Beam X-Ray Diffractometry |
Katsunari Sasaki, Masataka
Maeyama, Yukio Hirose and Toshihiko Sasaki |
|
| D-89
|
Next
Generation X-Ray Detector For In-House XRD (invited
paper) |
Taguchi Takeyoshi, Christian
Broennimann and Eric F. Eikenberry |
|
|
F-11
|
Grazing
Incidence XRF Analysis Of Tin Concentration Of Glass Surface |
Takashi Yamada, Masaru
Matsuo, Naoki Kawahara, Al Martin, Hisashi Inoue |
|
>>> Visit
the DXC 2007 website
|
|
Training
sessions |
|
X-ray
crystallography takes center stage at Fragment-Based Drug Discovery
Conference
|
|
Rigaku is pleased to announce the
following training sessions: - XRF:
- XRD (MiniFlex):
- XRD (Jade software):
- July 25-26 (27), 2007
- September 11-12 (13), 2007
- December 11-12 (13), 2007
- Macromolecular:
All
classes are held at the Rigaku applications laboratory in The Woodlands,
TX.
>>>
Click here for more information
|
|
ActiveSight® participated in the recent Fragment-Based Drug Discovery (FBDD)
conference, part of CHI's Drug Discovery Chemistry 2007 Conference, held in San Diego May
13-15.
ActiveSight's Chief Scientific Officer, Vicki Nienaber, co-organized a
pre-conference FBDD workshop with Rod Hubbard of Vernalis that covered the
basic principles and lessons learned over the past 10 years of FBDD. Vicki
pioneered X-ray structural methods and automation for FBDD during her time
at Abbott Labs, and has continued to lead successful FBDD programs at SGX
Pharmaceuticals and at ActiveSight. Through the years, Vicki has
successfully paired X-ray methods with NMR, surface plasmon resonance (SPR),
high concentration biochemical assays and most recently, calorimetry. At the
conference, Vicki served on a panel of experts who discussed the future of
FBDD.
ActiveSight's Exhibit at the 2007
Fragment-Based Drug Discovery (FBDD) Conference in San Diego. Rigaku
equipment is instrumental in the success of many FBDD programs,
including ActiveSight's. |
FBDD is a general method for discovery of
highly ligand efficient and readily optimizable lead compounds. A key
requirement for conducting a fragment screen is a method that can detect
weakly binding "fragments-of-leads". The conference reported a
number of these techniques that vary in sensitivity including established
techniques such as NMR and X-ray and rapidly emerging techniques such as SPR
and calorimetry. Although the FBDD technique is interdisciplinary, the
resounding message at the conference is the X-ray structural information is
ultimately needed for a successful FBDD program. The detailed
three-dimensional structure of a fragment bound to the protein is needed to
link or grow it into a drug-like lead. Hence, X-ray crystallography, already
an important tool for lead optimization, is seen as extending its reach
earlier into fragment-based lead identification and discovery.
FBDD is gaining popularity due to its
ability to generate novel leads quickly or to "scaffold hop" from
existing lead or drug compounds. Harren Jhoti of Astex discussed that it is
possible to go from initial studies of a drug target to putting a compound
into clinical trials in only two years, which by all accounts is much faster
than the industry average. Dr. Jhoti's presentation also highlighted the
importance of Astex's Rigaku system for their FBDD programs, including the
ACTOR robot crystal-mounting system.
ActiveSight has screened multiple target
classes by X-ray using the Rigaku Ultimate HomeLab™, featuring the
FR-E+
SuperBright™ microfocus generator and the ACTOR™ robot.
Via collaborations with the Scripps
Institute and PARC, ActiveSight is working to expand the field to
develop nanocalorimetry for fragment screening and the incorporation of SPR
and biochemical assays for routine fragment characterization. ActiveSight is also
collaborating with a well-known private
parallel synthesis organization to improve fragment optimization processes
and develop lead compounds against well-known drug targets. To identify
robust crystallization conditions and produce crystals for screening,
ActiveSight uses the Rigaku CrystalMation™ system. Automatic conversion of
X-ray data to maps in a readily viewable format is accomplished with
Rigaku's MIFit, originally developed by ActiveSight CEO Duncan McRee.
Want to learn how your structural research
can take center stage? FBDD can be leveraged by X-ray crystallography groups
in both industry and academia, providing value to any disease-related
research project. ActiveSight regularly holds regional FBDD workshops in the
major biotechnology hubs, and is hosting a FBDD conference in sunny San
Diego in February of 2008. Vicki Nienaber will also be discussing FBDD at
the lunch sponsored by Rigaku at the 2007 ACA meeting in July. For more
information, contact Mary
Canady.
>>> Learn more about ActiveSight
|
|
Travel
bursary |
|
Rigaku Americas Corporation will award summer travel bursaries in the
amount of U.S. $500 each to the five (5) post-doctoral fellows who
provide the most compelling explanation as to how they intend to pursue
a career in structural biology. Applications must be received by July
8, 2007.
>>> Click here for more information
|
|
SMI
represents Rigaku semiconductor products
| |
Coating
analysis using a benchtop Rigaku Mini-Z Zr analyzer
|
|
On June 1, 2007, Rigaku Corporation announced the signing of an agreement with
SMI, Inc. of Los Gatos, California as their exclusive sales
representatives in the United States for Semiconductor Fab Metrology
products. Sales Management Innovations (SMI) has put together a solid team of experienced manufacturers'
representatives to provide excellent regional sales coverage throughout the
U.S.
After a productive sales
meeting at Rigaku Americas Corporation in May, the team is already busy contacting customers and following up leads for wafer
analyzers, TXRF tools, and the MFM65 wafer metrology tool.
SMI is also offering the NitroGen series of liquid nitrogen generators on behalf of
RAC. Primary SMI contacts can now be reached via the Rigaku website.
| |
Coating is an important and common technology
used in various industrial fields. X-ray fluorescence (XRF) enables easy and
high-precision analysis for coating thickness without destruction or
consumption of sample. XRF also requires little or no simple sample
preparation to analyze coating thickness.
Designed to enhance corrosion protection or
to create a special surface appearance, conversion coatings are critical to
the aluminum beverage can industry. Trending towards environmental safety,
chromium-free conversion coatings—such as Zr—are becoming more
commonplace. WDXRF has been found to be an ideal analysis tool for
determining coating thicknesses in applications such as this. A Rigaku
Mini-Z Zr analyzer was used to demonstrate the ability of XRF in this
application.
Mini-Z analyzers are also available to
satisfy other coating needs, such as Si on paper or films or Ni on metals.
The Rigaku Mini-Z series consists of easy-to-operate benchtop
wavelength-dispersive XRF (WDXRF) instruments that analyze for a single
element. The optics are specifically designed for the particular element of
interest, allowing these instruments to deliver high-precision analysis
unexpected from such a compact benchtop unit.
>>> Click here
to request the Mini-Z Zr application note
|
|
What
are our customers saying?
|
|
Reciprocal
space mapping of epitaxial nanowires
|
|
"We're sold on Rigaku. We have purchased two Rigaku XRFs. The instrument is
the core our lab. We can not afford downtime or inaccurate data. The
applications department at Rigaku is very knowledgeable and helpful when
developing and updating curves. The service department is quick to respond to
our service needs and very competent. Their user classes are also very good."
—Susan Grierson
Gulf Chemical & Metallurgical Corporation
"We have been extremely
pleased with the user-friendly software and the exceptionally helpful
technical support team; so pleased, in fact that we recently purchased our
second unit. On the few occasions when we have experienced technical
difficulties, Rigaku's friendly and knowledgeable technical support team
has worked diligently and in a timely manner to help us fix the problem
either over the phone or by service call visit. From sale to service, the
staff at Rigaku is top notch."
—Stephanie Green
Pounding Mill Quarry Corporation Bluefield, Virginia
|
|
|

(004) reciprocal space map of a
two-dimensional InAs nanowire array with GaSb spacer grown epitaxially on
a GaSb (001) substrate. 3D contour map created by Rigaku's 3D Explore
software.
|
The
growth dynamics, and the ultimate electronic band structure—hence the
physical properties—of self-assembled epitaxial semiconductor nanowires
and dots depends on the strain states of epitaxial thin films, which are
functions of composition, morphology, and relaxation. High-resolution
X-ray reciprocal space mapping (RSM) provides a nondestructive, yet
quantitative, technique for the characterization of the strain,
composition, and morphology of multi-dimensional nanowire or nanodot
arrays. Rigaku's new Smartlab® automated diffractometer
makes reciprocal space mapping at medium, high, and very high resolution
much easier and faster with minimal user interference.
The SmartLab is designed for multi-purpose
applications, with a computer-guided, user-friendly optics system to
achieve variable resolutions for RSM measurements for single crystals and
epitaxial thin films. Rigaku's Cross Beam Optics (CBO) mirror—together
with a Ge(220)x2 or Ge(220)x4 or Ge(440)x4 monochromator—conditions the
incident X-ray beam into monochromatic radiation, with divergence down to
a few arc seconds. The automatically aligned Ge(220)x2 analyzer crystal on
the detector arm completes a triple-axis configuration for high-resolution
RSM measurements. The built-in Eulerian cradle and in-plane arm permits
RSM measurements to be carried out in regions usually not accessible by
conventional RSM methods.
In addition, SmartLab Guidance's
macro measurement capability allows multiple RSMs and other measurements,
such as rocking curves, to be completed in a single run.
>>> Click here
to request the full application note
|
|
What
else are our customers saying?
|
|
Introducing: NANOHUNTER |
|
"I have found the Rigaku XRF staff to be remarkably concerned about the function of the
ZSX in my lab, as well as extremely responsive to my needs. On issues as simple as the
location of a certain function in the software and as complex as the inevitable
hardware problem, the staff is very willing to work with me. I fully expected to
receive a lower level of support from Rigaku when my service contract expired. I am
pleased that this didn't happen; they have responded to my questions and helped with
every situation that has arisen. One XRF staff member, Al Martin, has even
solved problems for me via telephone in airports between flights. I truly appreciate this
quality of service."
—Nancy J. McMillan, Ph.D., AOJN
Department of Geological Sciences Dept. New Mexico State University
|
| NANOHUNTER
is the world's first benchtop total reflection X-ray fluorescence (TXRF)
spectrometer that provides both trace-level elemental analysis and
evaluation of the physical nature of the sample. Using patented switchable
wavelength and automated variable X-ray incidence angle excitation, this
instrument analyzes the full range of elements—from Al to U—in
solids, liquids, and powders. It also provides chemical information as a
function of analysis depth.
NANOHUNTER provides part-per-billion level
detection limits in a fully automated tool suitable for use by the
nonspecialist. Direct measurement of solids and powders provides freedom
from complex sample digestion or preparation, and makes this spectrometer
suitable for replacing or supplementing traditional atomic spectroscopy
methods. Compared to other trace-level atomic spectroscopy techniques, the
revolutionary aspect of the NANOHUNTER is the minimal level of sample
preparation required. It liberates the operator from ancillary equipment—like
fume hoods and microwave digesters—associated with a wet laboratory
environment.
The Rigaku NANOHUNTER's innovation is
not limited to extraordinary sensitivity for elemental analysis. The
ability to measure samples with an excitation beam that has a variable
grazing incidence angle allows the determination of additional physical
and chemical information. For the materials scientist involved in
nanotechnology research, this ability allows the nature of surface layers
to be characterized as particles on a substrate, a homogenous thin film,
or as something in between. While designed for the analysis of
contamination on—or diffusion into—advanced materials and thin films,
the system is also designed to be used for routine quantitative trace
elemental analysis of liquids, solids, or powders. With this power and
flexibility, the Rigaku NANOHUNTER opens a new chapter in atomic
spectroscopy.
>>> Click here for more information
|
|
|
What's
new
|
| Over
26,000 Ovonyx™ multilayer analyzers delivered |
|
Rigaku proudly announces over 26,000 Ovonyx
analyzer products have been built, tested and delivered.
Dr Yuriy Platonov and Mr
Gary Fournier lead the groups making multilayer coatings at Rigaku. |
Ovonyx multilayer analyzers are synthetic
analyzers made using thin-film sputtering, a nanotechnology process. These
innovative analyzers are used for light-element analysis in laboratory
wavelength dispersive spectrometers and WDXRF attachments for SEMs and electron
probe microanalysis (EPMA) instruments.
Many different Ovoynx multilayers exist,
each optimized for performance over a specific elemental range; some are
designed to achieve the best possible analysis of a single key element.
First offered in 1984, this product line
represents the original product developed by the optics group of Rigaku,
formerly known as Osmic. Multilayer analyzers are used by Rigaku and all other
instrument makers, for analysis of Si through Be.
>>> Click here for more
information about Rigaku optics products
|
|
What's new at
www.
Rigaku.com:
Take our
new survey to express your opinion about the Rigaku web site
|
| | 
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| | Rigaku
Americas Corporation: | Rigaku
Europe: | 9009 New Trails Drive The Woodlands,
Texas 77381-5209
U.S.A.
e-mail:
info@Rigaku.com Tel: (281)
362-2300 FAX: (281) 364-3628 | Unit B6, Chaucer Business Park Watery Lane, Kemsing Sevenoaks, Kent TN15 6QY, England
e-mail:
info@Rigaku.com Tel:
+44 1732 763 367 FAX: +44 1732 763 757 | |