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Rigaku nano3DX is a true X-ray microscope (XRM) with ultra-wide field of view, 25X larger volume than comparable systems, and three X-ray wavelengths for different matrices.Read more...
HyPix-3000 is a next-generation two-dimensional hybrid pixel array semiconductor detector designed specifically to meet the needs of the home lab diffractionist.Read more...
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Special Feature: Pharmaceutical Analysis (5): Analysis of trace impurities in pharmaceutical products using polarized EDXRF spectrometer NEX CG.Read more...
Quantitative analysis of crystalline forms
Identification of polymorphs in pharmaceutical products is a leading X-ray diffraction (XRD) application. The detection and quantification of polymorphic contamination is used to improve production efficiency and cost. In the study of different polycrystalline structures, within a drug compound, one polymorph is distinguished from another by a unique powder diffraction pattern associated with that specific crystal structure. Phase analysis can be restricted to qualitative identification only or can be extended to a full quantitative analysis. The analysis is applicable to polymorphs or to multi-component formulations. A special case of this type of analysis is "percentage crystallinity," where the volume percentage crystalline active ingredient to an amorphous filler is measured within a dosage formulation. X-ray diffraction analysis is also employed to study dosage formulations, under a variety of environmental conditions and over time, to characterize the formation of any polymorphs that could adversely affect performance and toxicity.
New 5th-generation general purpose benchtop XRD system for phase i.d and phase quantification
High-performance, multi-purpose XRD system for applications ranging from R&D to quality control