New Integrated HomeLab™ Solutions for Protein Crystallography Structure Determinations

New Integrated HomeLab™ Solutions for Protein Crystallography Structure Determinations

The Woodlands, TX — February 10, 2004. Rigaku today announced a family of integrated "home laboratory" solutions providing macromolecular X-ray crystallographers with everything from fully automated crystal screening to high-throughput structure determinations. Rigaku's HomeLab systems represent a balanced and optimized response to routine needs, in the pharma and biotechnology sectors, as well as specialized and unique combinations of extraordinary components for leading edge proteomics research.

Five distinct Rigaku HomeLab systems are now available, including the Phasing HomeLab, the Screening HomeLab, the Workhorse HomeLab, the High-Throughput HomeLab, and the Ultimate HomeLab. All of these systems consist of an X-ray generator, optics, a goniometer, a detector or choice of detectors, and a LN2-free cryogenic crystal cooling system. In addition, automation is added to the High-Throughput HomeLab, in the form of the ACTOR robot, for unattended 24/7 operation. Each system is optimized for a particular task—whether crystal screening, or phasing without the need for heavy atom derivatization, or simply providing a high performance to price ratio.

The Ultimate HomeLab represents the definitive example of such a system. Underlying the foundation of this premier system is a Rigaku FR-E+ SuperBright™ X-ray generator. Rigaku generators have long set the standard for excellence in terms of flux and reliability over years of operation. In this product, both X-ray ports are utilized - one is configured for small or poorly diffracting crystals with possibly large unit cells, and is equipped with VariMax-HR™ optics plus an R-AXIS HTC detector, while the second is configured for screening or fast data collection, for example, ligand binding studies, and features VariMax-HF optics with a Rigaku Saturn CCD detector. Thus concurrent protein crystal screening and data acquisition for protein crystal structure solutions can be performed in a home laboratory setting while affording the sort of performance associated with 2nd generation synchrotrons.

Rigaku—Leading With Innovation

Since its inception in Japan in 1951, Rigaku has been at the forefront of analytical and industrial instrumentation technology. Rigaku and its subsidiaries form a global group focused on life sciences and general purpose analytical instrumentation. With hundreds of major innovations to their credit, Rigaku companies are world leaders in the fields of small molecule and protein crystallography, X-ray spectrometry and diffraction, X-ray optics, as well as semiconductor metrology. Rigaku employs over 1,100 people in the manufacture and support of its analytical equipment. Its products are in use in more than 70 countries—supporting research, development, and quality assurance activities. Throughout the world, Rigaku continuously promotes partnerships, dialog, and innovation within the global scientific and industrial community.

For further information, contact:

Joseph D. Ferrara, Ph.D.
VP Product Marketing and CSO
Rigaku Americas Corporation
Tel: (281) 362-2300
eMail: Joseph D. Ferrara