Customized single crystal diffraction system with microfocus rotating anode generator

X-ray Crystal structure determination for macromolecules and chemicals

XtaLAB Synergy-Custom

We realize that standard systems may not fit the needs for every lab, so we also offer XtaLAB Synergy Custom single crystal X-ray diffractometers for those labs who want to take advantage of dual ports or want to integrate special components, such as ACTOR sample changers. The XtaLAB Synergy-Custom is configured with a MicroMax-007HF by default. The XtaLAB Synergy Custom may also be configured with the Excillum Liquid Metal Jet liquid gallium source. Additionally, for laboratories that want even greater flux we offer the FR-X based diffraction systems.

HPC detector

XtaLAB XtaLAB Synergy Custom systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, such as the HyPix-6000HE, PILATUS or EIGER. HPC detectors are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB Synergy Custom systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments.

Dual Port Capability

The XtaLAB Synergy Custom system includes a dual port, microfocus rotating anode X-ray generator. With XtaLAB Synergy Custom systems, you can configure to have dual single crystal ports or you can configure the second port with a small angle X-ray scattering system, such as the BioSAXS-2000nano. Additionally, the XtaLAB Synergy Custom comes in a custom designed enclosure with your choice of table size, to accommodate accessory equipment, such as an ACTOR system or microscope close to the goniometer. Thus, the versatility offered by the XtaLAB Synergy Custom system provides the most flexibility possible for your structural biology program .

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 The ultimate fully flexible single crystal X-ray diffractometer: The XtaLAB Synergy Custom
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Features

  • Customized systems for structural biology and chemical crystallography utilizing a high flux microfocus source
  • Your choice of source: MicroMax-007HF, Excillum Liquid Metal Jet or FR-X
  • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
  • Four-circle goniometer to provide completeness and redundancy for your data sets
  • HPC detector with single pixel point spread function and true shutterless data collection


HyPix-6000HE: Hybrid photon counting detector


detector
Rigaku Oxford Diffraction now offers the HyPix-6000HE Hybrid Photon Counting (HPC) detector. Like all HPCs, the HyPix-6000HE offers direct X-ray photon counting, single pixel point spread function and extremely low noise. The HyPix-6000HE HPC offers a small pixel size of 100 microns, which allows you to better resolve reflections for long unit cells as well as improving reflection profile analysis. The HyPix-6000HE has a high frame rate of 100 Hz, as well as a unique Zero Dead Time mode providing the ultimate in error-free shutterless data collection.
Detector   HyPix-6000HE
Active area   77.5 mm x 80.0 mm
Dynamic quantum efficiency (Cu-Kα) > 98%
Dynamic range 31-bits
Counting rate per pixel 1 x 10⁶ X-ray photons/sec
Readout speed 2.5 fps in ZeroDeadTime mode
Maximum frame rate 100 Hz
Point-spread function 1 pixel
Cooling Air-cooled
Humidity control Not required
Pixel size 100 μm x 100 μm

 


HyPix-Arc 150°: Curved photon counting X-ray detector


hypix-arc curved detector

The HyPix-Arc 150° is a unique, curved Hybrid Photon Counting (HPC) X-ray detector for single crystal diffraction applications. HyPix-Arc 150° has the highest 2θ range at a single position available for the home lab.

Collect more data in a single exposure with less reflection profile distortion:

The HyPix-Arc 150° offers 150 degrees angular coverage from edge to edge. This is more than enough to collect complete single crystal diffraction data, according to IUCr guidelines, for even Cu Kα X-ray wavelength from a single theta position. High and low angle data are measured at the same time, under the same conditions for better scaling, faster data and reduced dose time.

A curved detector minimizes peak distortion by ensuring that, even at short crystal-to-detector distances, diffracted beams are closer to perpendicular than is possible with a flat geometry.

Features:

  • Lowest reflection profile distortion
  • Faster data collection
  • Higher 2θ coverage in a single image
  • All reflections measured under the same conditions
  • Capture more diffracted photons per exposure


PILATUS3 R 200K: Low maintenance, direct photon counting detector


detector
The PILATUS3 R 200K is a hybrid photon counting (HPC) detector designed to achieve the best possible data quality for diffraction experiments. HPC detectors are direct-detection, single-photon counting devices that have essentially no noise and high sensitivity. Moreover, the high dynamic range excellent DQE characteristics for the PILATUS3 R 200K means that they it is well suited for accurately measuring weak reflections alongside very strong reflections - overload corrections and separate scans for weak and strong data are not necessary. The readout time for the PILATUS3 R 200K is 7 msec readout speed, making it capable of true shutterless data collection, thus removing errors associated with shutter open/close and goniometer start/stop events. HPC detectors have revolutionized the way data are collected at synchrotrons and the PILATUS3 R detectors bring those same capabilities to collect the best possible data at home.
Detector   PILATUS3 R 200K
Active area   83.8 mm x 70.0 mm
Sensor Reverse-biased silicon diode array
Dynamic quantum efficiency (Cu-Kα; Mo-Kα) > 98%; > 76%
Dynamic range 20-bits
Counting rate per pixel 2 x 10⁶ X-ray photons/sec
Readout speed 7 msec
Maximum frame rate 20 Hz
Point-spread function 1 pixel
Cooling Air-cooled
Humidity control Nitrogen or dry air flow
Pixel size 172 μm x 172 μm


PILATUS3 R 300K: Direct photon counting detector with larger active area


detector
The PILATUS3 R 300K is a hybrid photon counting (HPC) detector that is desirable by labs who desire the benefits offered by PILATUS detectors combined with 4-circle goniometers, but prefer a larger active area. HPC detectors are direct-detection, single-photon counting devices that have essentially no noise and high sensitivity. Moreover, the high dynamic range excellent DQE characteristics for the PILATUS3 R 300K means that they it is well suited for accurately measuring weak reflections alongside very strong reflections - overload corrections and separate scans for weak and strong data are not necessary. The readout time for the PILATUS3 R 300K is 7 msec readout speed, making it capable of true shutterless data collection, thus removing errors associated with shutter open/close and goniometer start/stop events. HPC detectors have revolutionized the way data are collected at synchrotrons and the PILATUS3 R detectors bring those same capabilities to collect the best possible data at home.
Detector   PILATUS3 R 300K
Active area   83.8 mm x 106.5 mm
Sensor Reverse-biased silicon diode array
Dynamic quantum efficiency (Cu-Kα; Mo-Kα) > 98%; > 76%
Dynamic range 20-bits
Counting rate per pixel 1 x 10⁷ X-ray photons/sec
Readout speed 7 msec
Maximum frame rate 20 Hz
Point-spread function 1 pixel
Cooling Water-cooled
Humidity control Nitrogen or dry air flow
Pixel size 172 μm x 172 μm


EIGER R 4M: Large format HPC detector


hypix
The EIGER R 4M is a new generation of hybrid photon counting (HPC) detector that combines exceptional data collection efficiency and resolving power with an active area rivaling that of CCDs and imaging plate detectors. HPC detectors are direct-detection, single-photon counting devices that have essentially no noise and high sensitivity. The EIGER R series is the latest generation of HPC detectors that feature auto-summation, which extends their digital counting ability up to 32-bits, or more than 4.2 billion counts, per pixel. Moreover, the EIGER R 4M delivers these high count rates with continuous readout, achieving duty cycles greater than 99%. The EIGER R 4M detector have small (75 μm) pixels with a single pixel point spread function to provide superior resolving power for reflections from samples with long unit cells, like macromolecules. In general, one can collect at sample-to-detector distances that are 20 - 30% shorter than those used for CCDs or PILATUS detectors. With this state of the art EIGER R 4M detector, you can unlock the true potential of your laboratory instrument.
Detector   EIGER R 4M
Active area   155.2 mm x 162.5 mm
Sensor Reverse-biased silicon diode array
Dynamic quantum efficiency (Cu-Kα) > 98%
Dynamic range 32-bits
Maximum count rate 5 x 10⁸ X-ray photons/sec
Readout speed Continuous readout, 10 μsec, duty cycle > 99%
Maximum frame rate 5 Hz
Point-spread function 1 pixel
Cooling Water cooled
Humidity control Nitrogen or dry air flow
Pixel size 75 μm x 75 μm
Description
ACTOR

ACTOR is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection.

ACTOR
PlateMate

The Rigaku PlateMate is a simple, inexpensive tool for rapid screening of crystals within crystallization plates. The PlateMate supports several different SBS format crystallization plates, though best results are observed using X-ray compatible plates. The PlateMate is quickly installed on Rigaku 4-circle AFC11 partial chi and non-inverted phi goniometers by virtue of the standard IUCr goniometer mount fitting.

(Requires partial chi option for CCD and PILATUS systems. IP systems may require a camera repositioning kit to modify camera angle for proper viewing of crystallization wells)

PlateMate
XtalCheck

The XtalCheck system includes software that facilitates both visual and diffraction imaging of crystallization experiments. With the XtalCheck system, one can easily survey many crystallization experiments by eliminating the need to harvest and cryo-cool samples. Moreover, one can perform serial crystallography experiments, by collecting data from multiple crystals, to achieve complete data sets that can be used for structure solution.

XtalCheck
EZ Aligner

The EZ Aligner tool allows for safe and remote alignment for VariMax or OptiSAXS optics. As the name implies, the EZ Aligner makes optimization of beam intensities an easy task. Simply set up your pin diode and pinhole, then use the EZ Aligner remote to optimize the beam from a safe place outside the radiation enclosure. Each EZ Aligner remote produces a radio signal strong enough to penetrate enclosure material or from another room. The EZ Aligner kit includes a remote control that communicates to 4 motors attached to optic micrometers to adjust optic rotation and translation.

EZ Aligner
Oxford Cryo 800

The Oxford Cryostream Cooler: The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.

Oxford Cryo 800
Oxford Cobra

The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.

Oxford Cobra

CrysAlisPro v40

Now with full 64 bit compatibility!

Rigaku Oxford Diffraction single crystal X-ray diffractometers come complete with CrysAlisPro, our user-inspired data collection and data processing software for small molecule and protein crystallography. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control.

CrysAlisPro logo

The latest release, CrysAlisPro v.40, is now fully 64 bit compatible and ready for the future. As modern diffractometers increase in performance and speed, your experiments generate bigger and bigger images and datasets. Additionally, supporting large detectors with very high pixel counts, such as those more commonly found at synchrotrons, requires large amounts of memory. Moving to 64 bit gives applications access to more memory, enabling the handling of these very large image sizes and data sets.

Expanded support for older Rigaku instrumentation and third party hardware is also in this release.

See below for other new software features that have recently been introduced.

How to get CrysAlisPro

The software is freely available for users of Rigaku Oxford Diffraction single crystal X-ray instruments and can be downloaded from our forum. Please register at http://www.rigakuxrayforum.com. Any queries related to the software may be answered on the forum.

CrysAlisPro: Seamless from start to finish

CrysAlisPro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution. Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible.

CrysAlisPro is built on a command line interface and the GUI retains full manual control options for those that want them. It is your choice how to analyse your data.

CrysAlisPro processes data using sophisticated algorithms to provide the highest quality data. As technology or approaches change, our software team incorporates these to further advance data analysis and processing.

CrysAlisPro screen
Processing of challenging and non-standard data collections

CrysAlisPro Ewald3D

CrysAlisPro contains a comprehensive and highly effective range of tools for tackling a wide range of samples from easy to challenging, and non-standard crystal samples. For example, EwaldExplorer and Ewald 3D (NEW!) easily identify effects, problems or artifacts in difficult or problematic datasets.

Ewald3D allows visualization of measured reciprocal space in 3-dimensions and in an undistorted way. Identifying diffuse scatter, modulation, subtle twinning, or incorrect instrument models is quick and easy with this brand new feature.

Supporting a range of crystallographic setups and applications

In addition to standard data collection routines, CrysAlisPro contains tools for working with non-standard experimental setups and sample types, including:

  • High pressure data collections
  • Variable temperature and multi-wavelength experiments
  • Powder experiments (data collection and processing)
  • Automatic screening or full data collections of several in situ protein crystals
  • Highly absorbing samples
  • Up to 8-fold twinned samples
  • Charge density measurements
  • Absolute structure determination
Software Compatibility

Exporting frames or data from CrysAlisPro into suitable alternative formats such as mosFLM, XDS, Denzo (HKL 2000) or another Esperanto format is easily achieved. Use CrysAlisPro’s data collection strategy to achieve the best data coverage in the quickest possible time and then automatically output into HKLF format for small molecule datasets or into the MTZ format for protein datasets.

CrysAlisPro is used by numerous research groups to process their synchrotron data. Our software is capable of importing data from several different detector types; known or unknown.


AutoChem

AutoChem is the ultimate productivity tool for small molecule chemists, offering fast, fully automatic structure solution and refinement during data collection. Developed in collaboration with OlexSys Ltd (Durham University, UK), AutoChem works in conjunction with Olex2 where more advanced structure solution and refinement functionality exists. AutoChem is seamlessly integrated within CrysAlisPro, and forms an integral part of our ‘What is this?’ feature.

The ‘What is this?’ feature gives you structures in seconds and ensures you are not wasting time collecting full datasets on known samples or starting materials. It is an alternative pre-experiment option, which is used to plan your full data collections.

CrysAlisPro flow
  1. López-Cabrelles J, Mañas-Valero S, Vitórica-Yrezábal J, Bereciartua P J, Rodríguez-Velamazán J A, Waerenborgh J C, Vieira B J C, Davidovikj D, Steeneken P G, van der Zant H S J, Minguez Espallargas G, Coronado E. “Isoreticular two-dimensional magnetic coordination polymers prepared through pre-synthetic ligand functionalization.” Nat. Chem. (2018) 10: 1001-1007 https://www.nature.com/articles/s41557-018-0113-9
  2. Lee T, Oshima Y, Cui H, Kato R. “Detailed X-band studies of the π-d molecular conductor λ-(BETS)2FeCl4: Observation of anomalous Angular dependence of the g-value.”J. Phys. Soc. Jpn. (2018) 87, 114702 https://journals.jps.jp/doi/pdf/10.7566/JPSJ.87.114702
  3. Yamashina M, Kusaba S, Akita M, Kikuchi T, Yoshizawa M. “Cramming versus threading of long amphiphilic oligomers into a polyaromatic capsule.” Nat. Comm. (2018) 9, 4227 https://www.nature.com/articles/s41467-018-06458-w.pdf
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