Cristalografía de proteínas/macromolecular

Estructura tridimensional (3D) de moléculas grandes para el diseño racional de fármacos

Cristalografía de proteínas/macromolecularEsta técnica utiliza difracción de rayos X de mono-cristal para inequívocamente determinar la estructura tridimensional de moléculas biológicas grandes. Los investigadores farmacéuticos y biotecnológicos necesitan entender como se controlan las enfermedades al nivel molecular (proteínas y macromoléculas relacionadas) para concentrar sus esfuerzos en las entidades correctas. Un prerrequisito de este método es la habilidad de obtener visualizaciones 3D de alta resolución de las macromoléculas de interés. Dado esto, Rigaku se posiciona en la vanguardia del desarrollo de una gran variedad de instrumentos relacionados con varios aspectos de la cristalografía macromolecular.

Sistemas

X-ray Diffraction systems
 
Synergy-R   XtaLAB Synergy-R
Single crystal X-ray diffractometer with MicroMax-007 HF microfocus rotating anode X-ray generator
  Synergy-S   XtaLAB Synergy-S
Fast, flexible single crystal X-ray diffractometer with the latest generation microfocus sources and HPC X-ray detectors, perfect for any crystallography lab.
 
Synergy Custom   XtaLAB Synergy Custom
Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components
   

SAXS systems 
 
BioSAXS-2000   BioSAXS-2000
Small angle X-ray scattering (SAXS) Kratky camera system
       
In Situ Crystallography 
 
PX Scanner   PX Scanner
Imaging and X-ray diffraction collection for crystals directly from crystallization plates
  PlateMate   PlateMate
Goniometer adapter for X-ray diffraction screening of samples in crystallization plates
  XtalCheck   XtalCheck
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
Reagents
 
Rigaku Reagents   Rigaku Reagents
Reagent kits, stock solutions, and accessories for
protein crystallography researchers
 

 

 

 Detectors 
 
HyPix-6000HE detector HyPix-6000HE detector
Hybrid Photon Counting (HPC) detector offering direct X-ray photon counting, single pixel point spread function and extremely low noise
PILATUS3 R detectors PILATUS3 R detectors
PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography
 Automatic Sample Changer 
 
ACTOR   ACTOR sample changer
Automated crystal transport, orientation and retrieval robot

Protein X-ray crystallography is a powerful structural biology technique that provides atomic resolution details about proteins and other macromolecular molecules involved in all aspects of life and disease. Rigaku is a world leader in providing instrumentation that can improve productivity at many levels — from making crystallization solutions and growing crystals to automatically mounting crystals and collecting high resolution single crystal X-ray diffraction data sets. Please select a system or component of interest to find out how Rigaku can assist you in your protein crystallography research.