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New Brochure for the Proteros Free Mounting® System

New Brochure for the Proteros Free Mounting® System

Integrated Solution for Optimization of Protein Crystals

The Woodlands, TX — May 4, 2005. Rigaku today announced the publication of a brochure that describes the newly introduced Proteros Free Mounting System (FMS). This four page document provides both an overview of capabilities as well as basic specifications. In addition to schematics illustrating product layout, the document describes routine operation of the instrument and provides a variety of examples illustrating performance.

Titled Free Mounting System: Macromolecular Crystal Optimization Tool for Dramatically Improving Crystallographic Data Quality, the brochure provides guidance for crystallographers seeking to either increase their productivity or rescue difficult crystal specimens. FMS represents a significant advance in that it can dramatically improve the quality of X-ray crystallographic data obtained for macromolecular structure determination. The system allows very accurate control of protein crystal water content, enabling the ability to greatly improve diffraction behavior of difficult crystals. Suitable for both beamlines and home lab applications, benefits include: resolution, mosaicity, and anisotropy optimization, improved cryo-protocols, as well as reduced X-ray background.

Free Mounting System is an integrated solution for optimization of protein crystals used in the collection of X-ray crystallographic data. Used in real-time conjunction with an X-ray diffractometer system, a protein crystal is mounted in a cryo-loop at room temperature and positioned in the center of a stream of gas for which the humidity and temperature are precisely controlled and adjustable. In this system, it is then possible to manipulate the crystal in different ways and simultaneously analyze diffraction behavior so as to optimize the crystal for the best possible diffraction resolution.

ROTEROS—New Dimensions in Protein Crystallography

Proteros Biostructures GmbH, located in Martinsried near Munich, Germany, is one of the worldwide leading experts in industrial X-ray structure analysis of proteins and protein-ligand-complexes for structure guided drug discovery. Proteros offers fast, reliable, and economic collaborations in high quality protein production and protein structure analysis supported by unique and proprietary technologies. Successful in business since 1999, Proteros collaborates with a large number of renowned international life science companies. The company's founders include Nobel Price Laureate Prof. Dr. Robert Huber, one of the pioneers of structural and functional analysis of proteins, who also made the original contributions for the development of the Free Mounting System.

Rigaku—Leading With Innovation

Since its inception in Japan in 1951, Rigaku has been at the forefront of analytical and industrial instrumentation technology. Rigaku and its subsidiaries form a global group focused on life sciences and general purpose analytical instrumentation. With hundreds of major innovations to their credit, Rigaku companies are world leaders in the fields of small molecule and protein crystallography, X-ray spectrometry and diffraction, X-ray optics, as well as semiconductor metrology. Rigaku employs over 1,100 people in the manufacture and support of its analytical equipment. Its products are in use in more than 70 countries—supporting research, development, and quality assurance activities. Throughout the world, Rigaku continuously promotes partnerships, dialog, and innovation within the global scientific and industrial community.

For further information, contact:

Joseph D. Ferrara, Ph.D.
VP Product Marketing and CSO
Rigaku Americas Corporation
Tel: (281) 362-2300
eMail: Joseph D. Ferrara