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Crystal system of pharmaceuticals accompanying changes in temperature and humidity [2]

AppNote B-XRD1021: phase changes of pharmaceuticals as a function of temperature and humidity

Background

The crystal systems of pharmaceuticals and foods may change due to factors such as temperature and humidity. The climate of Japan in particular exhibits extreme changes in temperature and humidity, with hot and humid summers, and dry, low-temperature winters, and these are poor conditions as an environment for synthesizing pharmaceuticals or storing foods. Therefore, there is a need to conduct measurement beforehand under various atmospheric conditions, and determine what sort of changes these materials undergo in the actual environment. Thus we evaluated thermal changes and changes in the crystal structure of pharmaceuticals by simultaneously measuring X-ray diffraction (XRD) and differential scanning calorimetry (DSC) while varying humidity.

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