Some of the compounds that make up pharmaceuticals take water into the crystal structure and change to hydrates with humidification. There is a correlation between crystal structure and physical properties, so it is important to understand the phase transition behavior due to changes in humidity when controlling the quality of hydrates. By measuring the XRD of a crystal powder while humidifying, the structural changes associated with humidification can be examined. Here, we investigated the hydration behavior of a pharmaceutical drug substance using simultaneous XRD-DSC and a humidity controller.
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