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Observation of phase transition behavior of pharmaceutical materials with a benchtop XRD system

AppNote B-XRD1133: Observation of phase transition behavior of pharmaceutical materials with a benchtop XRD system

Background

DSC measurements can be performed to identify dehydration or crystal phase transitions of pharmaceutical raw materials, but these measurements can only provide a prediction to identify the compounds created after reactions based on the melting point. On the other hand, X-ray diffraction measurements with sample heating (in-situ XRD) allow identification of the change in crystal structures due to heating. In the following example, the phase transition behavior of lactose monohydrate was examined using a combination of a benchtop XRD system and a temperature control attachment.

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