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Short data collection times on the BioSAXS-1000

AppNote BX003: Fast biological SAXS experiments

Background

The popularity of small angle X-ray scattering (SAXS) has increased in structural biology research because it is a useful technique to determine the shape and size of biological macromolecules in solution. Many SAXS experiments are performed at synchrotrons because of the short exposure times these high-intensity sources provide. However, getting beam time is competitive, beam time allotments are short, and the time in between synchrotron trips can be relatively long. The BioSAXS-1000 was designed to enable structural biologists to quickly collect SAXS data at home on their local X-ray source. The BioSAXS-1000 combines a focusing optic with Kratky beam collimation to achieve high X-ray fl ux on the sample without any need for data desmearing. Scattered X-ray photons are measured accurately by a highly sensitive DECTRIS® PILATUS 100K detector. As little as 15 μl of sample can be measured in the temperature-controlled sample holder.

SAXS products from Rigaku

Small angle X-ray scattering (SAXS) Kratky camera system

Small and wide angle X-ray scattering instrument designed for nano-structure analyses

Small and wide angle X-ray scattering instrument designed for nano-structure analyses

A modernized 2D Kratky system that eliminates data corrections required of traditional systems

Special CMF optic designed for SAXS instrumentation

Multipurpose products from Rigaku

Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components

Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

High-performance, multi-purpose XRD system for applications ranging from R&D to quality control