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Thaumatin S-SAD phasing with 2 hours of data collection on the XtaLAB Synergy-S

AppNote PX022 Fast protein single crystal X-ray diffraction and phasing experiment on the XtaLAB Synergy-S

Background

We recently introduced a sealed-tube 4-circle diffractometer for small molecule and macromolecular crystallography, the XtaLAB Synergy-S. It features three new technologies in a compact cabinet that will fit into any home laboratory: microfocus PhotonJet-S sources (with Cu, Mo, or Ag targets), an ultrafast (10 degrees per second) Kappa goniometer, and a HyPix-6000HE hybrid photon counting detector with 0.1 mm by 0.1 mm pixels. Here, we collected a two-hour data set on a thaumatin crystal to demonstrate the quality of data from the XtaLab Synergy-S system using a protein crystal with an average size unit cell.