Small molecule and macromolecular crystallographers use the same technique, often work in close proximity, and sometimes collaborate on the same projects, yet they are mostly separate in practice, many times even using separate diffractometers in the same room. Our newest diffractometers were designed around the concept of synergy of techniques. Here, we use our newest hybrid photon counting detector, the HyPix-Arc 150°, to demonstrate this synergy. We use the same instrument to collect atomic resolution data sets of lysozyme with and without sucrose bound and of sucrose by itself. We also solve all three structures by experimental phasing.