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Quantitative analysis of crystalline forms

Identification of polymorphs in pharmaceutical products is a leading X-ray diffraction (XRD) application. The detection and quantification of polymorphic contamination is used to improve production efficiency and cost. In the study of different polycrystalline structures, within a drug compound, one polymorph is distinguished from another by a unique powder diffraction pattern associated with that specific crystal structure. Phase analysis can be restricted to qualitative identification only or can be extended to a full quantitative analysis. The analysis is applicable to polymorphs or to multi-component formulations. A special case of this type of analysis is "percentage crystallinity," where the volume percentage crystalline active ingredient to an amorphous filler is measured within a dosage formulation. X-ray diffraction analysis is also employed to study dosage formulations, under a variety of environmental conditions and over time, to characterize the formation of any polymorphs that could adversely affect performance and toxicity.

Graphite and diamond are considered to be polymorphs, which means they are identical in the chemical aspect, but very different when it comes to crystal structure.

Rigaku recommends the following systems:

Single crystal

Our most popular diffractometer for Chemical Crystallography and Mineralogy, configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector.

Spectacular performance combined with dual wavelength versatility, provides the perfect answer for high-capacity Chemical Crystallography labs or for X-ray facilities that support Chemical Crystallography and Protein Crystallography.

An entry-level single crystal X-ray diffractometer for Chemical Crystallography configured with microfocus sealed tube technology and a direct X-ray detection detector.

A benchtop single crystal X-ray diffractometer ideal for chemical crystallography and teaching.


Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

Small Molecule

User-inspired data collection and data processing software for small molecule and protein crystallography.

Rigaku's new automated optic alignment solution makes X-ray optic alignment trivial, ensuring peak performance all the time.

The smallest detachable motorized goniometer head on the market.


Extremely low noise, compact, detector based on direct X-ray detection technology.


Handheld Raman for raw material identification and finished product authentication using 1064 nm Raman analysis.