Skip to main content

Analysis of Very Small Organic Crystals with the XtaLAB Synergy-S

AppNote SMX016 Analysis of Very Small Organic Crystals with the XtaLAB Synergy-S

Background

As research projects multiply and diversify, and chemists attempt the synthesis of ever more exotic molecules, the isolation and crystallization of these molecules for subsequent characterization often represents the bottleneck for advancement of the project. So when crystallographers are presented with a batch of tiny crystals, they must be able to rely on a powerful X-ray diffractometer to collect the data required to elucidate the structure of these new compounds and characterize them without any ambiguity. To address such difficult applications, the Rigaku Oxford Diffraction XtaLAB Synergy-S diffractometer features a powerful 50 watt microfocus sealed tube with a small FWHM beam size of 110 µm, ensuring that most of the X-ray photons are concentrated on the important area, the crystal. In addition, the Rigaku Oxford Diffraction XtaLAB Synergy-S is configured with a HyPix-6000HE hybrid photon counting (HPC) detector. HPC detectors have been used at most synchrotron beamlines around the World because of their high sensitivity and very low electronic noise. These features are also critical to collect precise and accurate data on weakly diffracting crystals on home diffractometers. Here, we demonstrate the performance of the XtaLAB Synergy-S on a tiny organic crystal of benzophenone.

A very small crystal of benzophenone, with dimensions 0.015 x 0.018 x 0.027 mm³, was captured on a MiTeGen Kapton loop mounted on a magnetic base, using paratone oil. The crystal was mounted on the goniometer, centered in the beam using a video camera and data were collected at 100 K with the Rigaku Oxford Diffraction program CrysAlisPro.

Small molecule crystallography products from Rigaku

A benchtop single crystal X-ray diffractometer ideal for self-service crystallography and teaching.

Our most popular diffractometer for chemical crystallography, configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector.

An extremely high-flux rotating anode X-ray diffractometer specifically configured for measuring difficult samples.

A dual-wavelength, extremely high-flux, rotating anode X-ray diffractometer specifically configured for measuring difficult samples as well as providing versatility through multiple wavelengths.

A modern single crystal X-ray diffractometer for structural analysis of small molecule samples configured with microfocus sealed tube technology and a direct X-ray detection detector.

A bespoke, extremely high-flux diffractometer with custom enclosure and the flexibility to utilize both ports of the rotating anode X-ray source.

User-inspired data collection and data processing software for small molecule and protein crystallography

A unique curved single crystal X-ray diffraction detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.

Extremely low noise, air-cooled X-ray detector based on direct X-ray detection technology.

Extremely low noise, compact, air-cooled X-ray detector based on direct X-ray detection technology.

High-resolution X-ray detectors for X-ray diffractometers from DECTRIS

Automated crystal transport, orientation and retrieval robot

The smallest detachable motorized goniometer head on the market