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Comparison of drugs

TA-6005: Comparison of drugs

 

We perform comparative analysis for three over-the-counter products. Although even if main components of drug are same, the drugs become different due to the other factors such as diluent base, preservation agent and process of manufacture occasionally. And also, it is rare case, but it should be possible to consider pure grade of main components. We can observe the minute-difference between three over-the-counter products because of analyzing the detail of thermal cracking process for drugs in inert atmosphere using the combination of thermogravimetry (TG) and mass spectrometer (MS).

Thermal analysis products from Rigaku

TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).

 

 

DSC is a thermal analysis technique that quantifies the amount of energy in a reaction.

Quantifies the energy changes in reactions such as melting, transition, crystallization and glass transition temperature.

DSC8271 is a high-temperature type DSC with a maximum temperature of 1,500°C.

TMA is the measurement of a change in dimension or mechanical property of the sample while it is subjected to a controlled temperature program.

 

The compact humidity generator (HUM-1) is connected to the TG-DTA for measurements under constant relative humidity water vapor atmosphere.

 

TMA/HUM measures change in dimension or mechanical property of a sample while subjected to a temperature regime under water vapor atmosphere with a constant relative humidity.

Thermo Mass Photo combines simultaneous thermal analysis with mass spectrometry. This technique is suitable for the qualitative analysis of  evolved gases coincident with the STA signal.

In TG-FTIR, gases evolved by volatilization or thermal decomposition are qualitatively analyzed, which allows you to track changes in the generated amount along with the temperature change.