FT-IR and Raman are proven optical-based techniques used to identify a variety of chemical substances and compounds in a number industries. Sometimes used as complimentary technologies, each provide benefits and advantages. However for safety and security applications, FT-IR has often been regarded as the most effective analytical technique for identification of many chemical substances and compounds. In comparison, Raman has not been considered as a technically equal or superior method for identification or verification purposes. The purpose of the study was two-fold. First, to gain a better understanding of the differences and similarities between the two techniques by comparing results generated by FT-IR and Raman systems. Second, to provide tangible data that decision makers involved in safety and security applications can utilize to select the technology best suited for their requirements.