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Phase ID analysis of micro-impurities on the surface of a tablet by micro-area XRD measurement

AppNote B-XRD1137: Phase ID analysis of micro-impurities on the surface of a tablet by micro-area XRD measurement

Background

Medicines generally consist of an active ingredient (active pharmaceutical ingredient) and diluents for pharmaceutical formulation. The most common form of a drug product is a tablet. If a coloring agent has adhered to the surface of a tablet during the tableting process using a tableting machine, the substance can be analyzed to identify the changes in the tablet’s composition and the source of the contamination. In this measurement, we determined the crystal phase of a red-colored material adhering to the surface of a mock tablet and the presumed the source of the contamination.

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