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Protein / macromolecular crystallography

Protein crystallography

3D structure of large biological molecules

This technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three-dimensional structure of large biological molecules. The determination of such molecules gives researchers insight into biology and life at the molecular level.  Given the importance of this research, Rigaku has been at the forefront in the development of a wide range of instrumentation related to various aspects of macromolecular crystallography.

One important application is structure-based drug design, a technique by which drugs are designed based on a knowledge of the three-dimensional structure of an enzyme’s active site.

Rigaku recommends the following products:

Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab

Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality

Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality

Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality

PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography

Systems

Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

Detectors

Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality

High-resolution X-ray detectors for X-ray diffractometers from DECTRIS

Automation products

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Automated crystal transport, orientation and retrieval robot

Automated crystal transport, orientation and retrieval robot

Automated crystal transport, orientation and retrieval robot

Accessories

Single wavelength Confocal Max-Flux (CMF) optics for single crystal diffraction

User-inspired data collection and data processing software for small molecule and protein crystallography