Determine the three dimensional structure of molecules
Chemical or small molecule crystallography is a technique that employs single crystal X-ray diffraction (SCX) to unambiguously determine the three-dimensional structure of molecules. When molecules crystalize (think sugar) they form a three-dimensional regular arrangement of molecules. X-rays are diffracted by crystals and the diffraction pattern so created can be measured and analyzed to determine the atomic arrangements within the molecule being studied. The technique provides accurate and precise measurements of molecular dimensions in a way that no other method can approach. The technique may be applied to compounds of both chemical and biological interest, including new synthetic chemicals, catalysts, pharmaceuticals, and natural products. A frequent use is the identification of natural products, or of the products of synthetic chemistry experiments; however, detailed molecular geometry, intermolecular interactions and absolute configuration can also be studied.
See the article "What is This?" A Structure Analysis Tool for Rapid and Automated Solution of Small Molecule Structures by Takashi Matsumoto, Akihito Yamano, Takashi Sato, Joseph D. Ferrara, Fraser White and Mathias Meyer in Journal of Chemical Crystallography.
Some of the important information that can be derived from this technique include:
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Application notes
The following application notes are relevant to this applicationSmall Molecule, Single crystal
Small Molecule
Protein, Single crystal
Rigaku recommends the following systems:
A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab
Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator
Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments
Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments
An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples
Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components
User-inspired data collection and data processing software for small molecule and protein crystallography
Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality
Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality
Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality
Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality