Dr. Satoshi Omura of Kitasato Univerisity and his collaborator, Dr. William C. Campbell of Merck, were awarded the 2015 Nobel Prize in Physiology or Medicine “for their discoveries concerning a novel therapy against infections caused by roundworm parasites”. What they discovered is the breakthrough medicine ivermectin which cures onchocerciasis, an...
X-ray diffraction is an analytical method for the characterization of the crystalline structure of a material, where the X-ray intensity (I) variation is recorded as a function of diffraction angle (2θ). The diffraction region where 2θ≦10° is called the Small Angle X-ray Scattering (SAXS) area, and the area where 2θ≧5°...
The previous series have discussed single crystal X-ray analysis of small molecules. This series will discuss structure analysis of proteins using X-ray diffraction. The explanation will focus in particular on differences between structure analysis of proteins and that of small molecules.
In structure analysis of proteins or small molecules, the...
The general preparation method of fusion bead, equipment, reagents and other important considerations were described in the previous article “Sample preparation for X-ray fluorescence analysis IV Fusion bead method—part 1 basic principles.” In this article, the preparation methods of various applications such as ferroalloy, sulfide and carbide are described.
Quality control is a top priority for the pharmaceutical industry. RMID (raw material identification) is an important part of quality control. Since health authorities of many countries including Japan joined PIC/S recently, quick and reliable RMID is becoming more important.
In the field of RMID, IR (infrared) and NIR (near...
X-ray fluorescence spectrometry is one of the common instrumental analysis techniques for routine quality control. This is due to high precision and easy sample preparation compared to other instrumental analytical methods. It is also a powerful analytical tool in the field of research and development for the analysis of advanced...
X-ray fluorescence spectrometry (XRF) is well known as an analysis method with high precision by means of non-destructive and no contact analysis, and is therefore widely used for process and quality control at production sites.
In particular, total reflection X-ray fluorescence spectrometry (TXRF) developed in the 1970s is a special...
X-ray topography is a powerful technique for evaluating crystal defects such as dislocations, stacking faults, scratches, and so on. High–performance electronics devices such as microprocessors, solid-state memories, imaging processors are fabricated on dislocation-free Si single crystal wafers. However, device fabrication processes often induce dislocations in the Si wafers that can...
There are two basic objectives in scientific analysis of tangible cultural properties: appraisal of authenticity, and investigation of materials for purposes of preservation or restoration. Targets of these analyses are buildings, sculptures, paintings, craft objects, old documents and so on.
Among the various analysis techniques, single crystal X-ray structure analysis can be regarded as the most effective analysis technique for acquiring knowledge about the 3-dimensional configuration of molecules. However, in single crystal X-ray structure analysis, there is also a major problem in that measurement cannot be done if the target...
For the analysis of powders by XRF, sample inhomogeneity due to segregation, grain size and mineralogical effects influence X-ray intensity and can cause analysis errors. It is therefore recommended to analyze powder samples after fine pulverizing as described in “Sample Preparation for X-ray Fluorescence Analysis II. Pulverizing methods of powder...
Hyphenated methodology combined with thermal analysis and other analysis methods has been widely applied to the investigation of complex phenomena. Thermo Mass Photo is a thermogravimetry-differential thermal analysis-mass spectrometry (TG-DTA-MS) instrument, which is one of the most widespread hyphenated systems, and a main product in the lineup of Rigaku’s evolved...
Thermo Mass Photo is a thermogravimetry-differential thermal analysis-mass spectrometry (TG-DTA-MS) instrument and a main product in the lineup of Rigaku’s evolved gas analytical systems. It consists of thermogravimetry-differential thermal analysis (TG-DTA) and photoionization mass spectrometry (PIMS) equipped with a skimmer-type interface. Weight change, endothermic or exothermic phenomena, and evolved gases...
SmartLab Studio II is an integrated X-ray diffraction software package for SmartLab 3, an automated multipurpose X-ray diffractometer. The package covers the full spectrum of operations required for X-ray diffraction analysis, including measurement, analysis, data display and reporting on a single platform. SmartLab Studio II is designed from the ground...
I would like to take this opportunity to address the recent acquisition of Agilent’s XRD business by Rigaku Corporation and the subsequent creation of a new combined Rigaku Oxford Diffraction single crystal group.
Our decision to make this acquisition was based on a number of things, but key among those...
