SAXS: biological

Protein envelope shape and folding in solution

SAXS also complements other techniques in structural biology. For instance, a solution scattering curve can be readily calculated using a set of atomic coordinates derived from macromolecular crystallography, providing a means of comparing solution structures with crystal structures. Structural changes induced by ligand binding, or changes in other chemical or physical environment, can be monitored using solution scattering and interpreted based on high-resolution structures derived from other techniques. Solution scattering can help model a large molecular complex whose over-all structure is unknown but where the structures of individual components are available.


Small angle X-ray scattering (SAXS) Kratky camera system
Small angle X-ray scattering (SAXS) pin-hole camera system