Protein/macromolecular crystallography

3D structure of large molecules for rational drug design

This technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three dimensional structure of large biological molecules. Pharmaceutical and biotechnology researchers need to understand how disease is controlled at the molecular level within proteins and related macromolecules so as to target specific entities based on this knowledge. A prerequisite for this approach is the ability to obtain a high-resolution 3D molecular structure of the macromolecule under investigation. Given the importance of this research, Rigaku has been at the forefront in the development of a wide range of instrumentation related to various aspects of macromolecular crystallography.


X-ray Diffraction systems
  XtaLAB MM003
Single crystal diffraction system with microfocus sealed Tube X-ray source
    XtaLAB Synergy-S
Fast, flexible system with the latest generation sources and HPC detectors, perfect for any crystallography lab.
  XtaLAB MM007-HF
Single crystal diffraction system with microfocus rotating anode generator
    XtaLAB FR-X
Single crystal diffraction system with microfocus rotating anode generator


SAXS Systems

SAXS systems 
Small angle X-ray scattering (SAXS) Kratky camera system
Small angle X-ray scattering (SAXS) pin-hole camera system

In Situ Crystallography

In Situ Crystallography 
  PX Scanner
Imaging and X-ray diffraction collection for crystals directly from crystallization plates
Goniometer adapter for diffraction screening of samples in crystallization plates
Automated tool for performing in situ crystallography experiments on existing X-ray diffraction systems


  Rigaku Reagents
Reagent kits, stock solutions, and accessories for
protein researchers



X-ray Generators

 X-ray generators
High intensity microfocus rotating anode X-ray generator
    MicroMax-007 HF
Microfocus rotating anode X-ray generator
Microfocus high-intensity sealed tube X-ray source


PILATUS3 R detectors
PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography
HyPix-6000HE detector
Hybrid Photon Counting (HPC) detector offering direct X-ray photon counting, single pixel point spread function and extremely low noise



Single wavelength Confocal Max-Flux® (CMF) optics for protein crystallography
    VariMax DW
Dual wavelength Confocal Max-Flux® (CMF) optics for protein crystallography

Accessories and Software

 Accessories and Software 
Real-time remote monitoring for diffraction experiments
Data collection, processing and structure solution software
    ACTOR sample changer
Automated crystal transport, orientation and retrieval robot

Protein crystallography is a powerful structural biology technique that provides atomic resolution details about proteins and other macromolecular molecules involved in all aspects of life and disease. Rigaku is a world leader in providing instrumentation that can improve productivity at many levels — from making crystallization solutions and growing crystals to automatically mounting crystals and collecting high resolution X-ray diffraction data sets. Please select a system or component of interest to find out how Rigaku can assist you in your protein crystallography research.