Protein/macromolecular crystallography

3D structure of large molecules for rational drug design

This technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three dimensional structure of large biological molecules. Pharmaceutical and biotechnology researchers need to understand how disease is controlled at the molecular level within proteins and related macromolecules so as to target specific entities based on this knowledge. A prerequisite for this approach is the ability to obtain a high-resolution 3D molecular structure of the macromolecule under investigation. Given the importance of this research, Rigaku has been at the forefront in the development of a wide range of instrumentation related to various aspects of macromolecular crystallography.

Systems

X-ray Diffraction systems
 
  XtaLAB MM003
Single crystal diffraction system with microfocus sealed Tube X-ray source
    XtaLAB MM007-HF
Single crystal diffraction system with microfocus rotating anode generator
    XtaLAB FR-X
Single crystal diffraction system with microfocus rotating anode generator
 

SAXS systems 
 
  BioSAXS-2000
Small angle X-ray scattering (SAXS) Kratky camera system
    S-MAX3000
Small angle X-ray scattering (SAXS) pin-hole camera system
   
 
In Situ Crystallography 
 
  PX Scanner
Imaging and X-ray diffraction collection for crystals directly from crystallization plates
    PlateMate
Goniometer adapter for diffraction screening of samples in crystallization plates
   
 
Reagents
 
  Rigaku Reagents
Reagent kits, stock solutions, and accessories for
protein researchers
     
 
 

X-ray generators
 
  FR-X
High intensity microfocus rotating anode X-ray generator
    MicroMax-007 HF
Microfocus rotating anode X-ray generator
    MicroMax-003
Microfocus high-intensity sealed tube X-ray source
 

Detectors 
 
PILATUS3 R detectors
PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography
R-AXIS IV++
Large-area imaging plate X-ray area detector


 Optics

       
 
  VariMax
Single wavelength Confocal Max-Flux® (CMF) optics for protein crystallography
    VariMax DW
Dual wavelength Confocal Max-Flux® (CMF) optics for protein crystallography
   
 

Accessories and Software

       
 
  RigakuRemote
Real-time remote monitoring for diffraction experiments
    HKL-3000R
Data collection, processing and structure solution software
    ACTOR sample changer
Automated crystal transport, orientation and retrieval robot