Single Crystal Diffraction System with Microfocus Rotating Anode Generator

Structure determination of macromolecules


The XtaLAB FR-X system includes a VariMax optic coupled with the FR-X rotating anode generator. The FR-X is the most intense home lab X-ray source in the world and enables data collection on the widest range of protein crystal samples. It delivers 2.5 times higher flux compared to the MicroMax-007 HF rotating anode generator but shares the same microfocus 70 μm focal spot size. When coupled with Rigaku’s VariMax optics, the FR-X delivers the highest brilliance for any commercially available rotating anode. As a result, it is possible to collect diffraction data for samples where no diffraction can be seen using a conventional rotating anode or sealed tube source.

HPC detector

The XtaLAB FR-X system can be configured with a Hybrid Photon Counting (HPC) detector, such as the HyPix-6000, PILATUS or EIGER. HPC detectors are ideal for this type of source because they are photon counting detectors that directly detect X-ray photons without the need the intermediate step of converting X-ray photons to light with a phosphor, because they have high dynamic range and fast readout speed, and because they have extremely low noise. Additionally, HPC detectors have an ideal point spread function of a single pixel. These combined features, along with shutterless data collection, means that you can collect more accurate data faster. As a result, the XtaLAB FR-X system offers outstanding performance for macromolecular experiments.

Dual Port Capability

The XtaLAB FR-X system includes two X-ray ports, allowing you to configure a system with dual single crystal ports or you can configure the second port with a small angle X-ray scattering system, such as the BioSAXS-2000. Thus, the versatility offered with two ports provides an efficient way to expand your structural biology program.

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  • True microfocus rotating anode X-ray sources with outstanding beam stability
  • Robust direct-drive anode provides extended anode and filament lifetimes
  • Increased uptime and ease of use with pre-aligned and pre-aged filaments
  • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
  • Four-circle goniometer to provide completeness and redundancy for your data sets
  • HPC detector with single pixel point spread function and true shutterless data collection
  • HKL-3000R for instrument control, data processing and structure solution
  • Dual ports allow for dual detectors or dual crystallography and SAXS ports, with NO compromise in beam intensity
  • Dual wavelength option - for in-house phasing or dual macro- and small molecule capabilities

FR-X Specifications

The Rigaku FR-X is the most intense home laboratory X-ray source available today, providing brightness exceeding some second generation bending magnet synchrotron beamlines. Ideal for many applications requiring a very bright X-ray beam, the FR-X provides the flux you need, where you need it: on your sample.

X-ray generator
Maximum power 2.97 kW
Voltage 20-60 kV, in 1 kV steps
Current 10-60 mA, in 1 mA steps
HV stability¹ ±0.01%
Power requirements 3-phase 200 VAC, 20 A, 50/60 Hz
Anode assembly
Available targets Cu, Co, Cr, Mo, Co/Cu, Cr/Cu and Mo/Cu
(others available upon request)
Diameter 280 mm
Rotation speed 12000 rpm
Drive mechanism Direct drive
Vacuum seal High-speed ferrofluid
Shaft bearing material Ceramic ball bearing
Water seal Mechanical
Tube tower assembly
X-ray window 0.2 mm thick beryllium
Available ports 2
Shutter type High-speed rotary, one per port
Vacuum Integrated turbo-molecular pump
X-ray source data
Filament W, annealed and pre-aligned
Take-off type Horizontal point focus
Effective size at 5° take-off angle 0.07 mm circle for Cu, Cr and Co
Beam fluence at sample position
With Cu anode and VariMaxHF Arc)Sec optic
at 100 μm sample and 4.8 mR divergence
24×10¹⁰ X-rays/mm²/sec
With Cu anode and VariMax VHF Arc)Sec optic  
at 100 μm sample and 10 mR divergence
57×10¹⁰ X-rays/mm²/sec

¹ For a ±10% variation in line voltage and ±5% change in ambient temperature between 10°C and 25°C

Detector name
Active area
Readout times
PILATUS3 R 200K 83.8 mm x 70 mm 7 msec
PILATUS3 R 300K 83.8 mm x 106.5 mm 7 msec
EIGER R 1M 77.2 mm x 79.9 mm Continuous readout, 4 μs deadtime
EZ Aligner

The EZ Aligner tool allows for safe and remote alignment for VariMax or OptiSAXS optics. As the name implies, the EZ Aligner makes optimization of beam intensities an easy task. Simply set up your pin diode and pinhole, then use the EZ Aligner remote to optimize the beam from a safe place outside the radiation enclosure. Each EZ Aligner remote produces a radio signal strong enough to penetrate enclosure material or from another room. The EZ Aligner kit includes a remote control that communicates to 4 motors attached to optic micrometers to adjust optic rotation and translation.


ACTOR is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection.


RigakuRemote offers the ability to remotely monitor the status of a single crystal X-ray system from anywhere you can get an internet connection. It provides real-time updates of the state of your instrumentation, including video of the crystal and enclosure. Also included are current information about the scans being collected, and a JPEG view of the last diffraction image collected.


The Rigaku PlateMate is a simple, inexpensive tool for rapid screening of crystals within crystallization plates. The PlateMate supports several different SBS format crystallization plates, though best results are observed using X-ray compatible plates. The PlateMate is quickly installed on Rigaku 4-circle AFC11 partial chi and non-inverted phi goniometers by virtue of the standard IUCr goniometer mount fitting.

(Requires partial chi option for CCD and PILATUS systems. IP systems may require a camera repositioning kit to modify camera angle for proper viewing of crystallization wells)

Oxford Cryo 800

The Oxford Cryostream Cooler: The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.

Oxford Cobra

The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.


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