Single Crystal Diffraction System with Microfocus Rotating Anode Generator

Structure determination of macromolecules


The XtaLAB MM007-HF system includes a VariMax optic coupled to the MicroMax-007 HF, which provides the best balance between outstanding performance for a wide range of crystal types. As the most popular microfocus rotating anode X-ray source for structural biology, the Rigaku MicroMax-007 HF provides brilliance equaling the very best competitive products with a smaller focal spot and while providing lower cost-of-ownership and higher productivity. High uptimes and "designed-in" maintainability differentiate the MicroMax-007 HF from the competition. The MicroMax-007 HF rotating anode generator offers two ports and can be equipped with detector systems on each. Alternatively, one port can be configured for biological SAXS experiments.

HPC detector

The XtaLAB MM007HF system is coupled with a Hybrid Photon Counting (HPC) detector, such as the HyPix-6000 or PILATUS3 R 200K hybrid photon counting detector (HPC). HPC detectors are ideal for this type of source because they are photon counting detectors that directly detect X-ray photons without the need the intermediate step of converting X-ray photons to light with a phosphor, because they have high dynamic range and fast readout speed, and because they have extremely low noise. Additionally, HPC detectors have an ideal point spread function of a single pixel. These combined features, along with shutterless data collection, means that you can collect more accurate data faster. As a result, the XtaLAB MM007HF system offers outstanding performance for macromolecular experiments.

Dual Port Capability

The XtaLAB MM007HF system offers two ports, allowing you to configure a system with dual single crystal ports or you can configure the second port with a small angle X-ray scattering system, such as the BioSAXS (link to BX2000 page). Thus, the versatility offered with two ports provides an efficient way to expand your structural biology program.

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  • True microfocus rotating anode X-ray sources with outstanding beam stability
  • Robust direct-drive anode provides extended anode and filament lifetimes
  • Increased uptime and ease of use with pre-aligned and pre-aged filaments
  • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
  • Four-circle goniometer to provide completeness and redundancy for your data sets
  • HPC detector with single pixel point spread function and true shutterless data collection
  • HKL-3000R for instrument control, data processing and structure solution
  • Dual ports allow for dual detectors or dual crystallography and SAXS ports, with NO compromise in beam intensity
  • Dual wavelength option - for in-house phasing or dual macro- and small molecule capabilities

MicroMax™-007 HF specifications

X-ray generator

  • Maximum power: 1.2 kW
  • Voltage: 20 – 60 kV, in 1 kV steps
  • Current: 10 – 30 mA, in 1 mA steps
  • HV stability: ±0.015 %
  • Power requirements: 3-phase 200/220 VAC, 12 A

Anode assembly

  • Available targets: Cu, Cr, Mo and Co
  • Diameter: 99 mm
  • Rotation speed: 9000 RPM
  • Drive mechanism: Direct-drive
  • Vacuum seal: Low-torque magnetic fluid
  • Shaft bearing material: Ceramic ball bearing
  • Water seal: Mechanical

Tube tower assembly

  • X-ray window: 0.2 mm thick beryllium
  • Available ports: 2
  • Shutter type: High-speed rotary, one per port
  • Vacuum: Integrated turbo-molecular pump

X-ray source data

  • Filament: W, annealed and pre-aligned
  • Take-off type: Horizontal point focus
  • Effective size at 6° take-off angle: 0.07 mm circle for Cu, Cr and Co, 0.15 x 0.1 mm ellipse for Mo




Focal spot size (μm) all optics φ = 70
Power (kW) all optics 1.2
Beam size at sample (μm) VariMax HF <250
VariMax HF Arc)Sec <200
VariMax VHF <150
VariMax VHF Arc)Sec <110
Divergence (mR) VariMax HF 4.8
VariMax HF Arc)Sec 4.8
VariMax VHF 10.0
VariMax VHF ArcSec 10.0

Detector name
Active area
Readout times
PILATUS3 R 200K 83.8 mm x 70 mm 7 msec
PILATUS3 R 300K 83.8 mm x 106.5 mm 7 msec
EIGER R 1M 77.2 mm x 79.9 mm Continuous readout, 4 μs deadtime
HyPix 77.5 mm x 80.3 mm Up to 100 Hz
EZ Aligner

The EZ Aligner tool allows for safe and remote alignment for VariMax or OptiSAXS optics. As the name implies, the EZ Aligner makes optimization of beam intensities an easy task. Simply set up your pin diode and pinhole, then use the EZ Aligner remote to optimize the beam from a safe place outside the radiation enclosure. Each EZ Aligner remote produces a radio signal strong enough to penetrate enclosure material or from another room. The EZ Aligner kit includes a remote control that communicates to 4 motors attached to optic micrometers to adjust optic rotation and translation.


ACTOR is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection.


The Rigaku PlateMate is a simple, inexpensive tool for rapid screening of crystals within crystallization plates. The PlateMate supports several different SBS format crystallization plates, though best results are observed using X-ray compatible plates. The PlateMate is quickly installed on Rigaku 4-circle AFC11 partial chi and non-inverted phi goniometers by virtue of the standard IUCr goniometer mount fitting.

(Requires partial chi option for CCD and PILATUS systems. IP systems may require a camera repositioning kit to modify camera angle for proper viewing of crystallization wells)

Oxford Cryo 800

The Oxford Cryostream Cooler: The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.

Oxford Cobra

The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.


HKL-3000R represents a new approach in crystallographic data collection software that integrates data collection, data reduction, phasing and model building into a single package. This approach significantly accelerates the process of structure determination and on average minimizes the number of crystals, data sets and time required for structure solution.

HKL-3000R Is the Most Widely Used Processing Package for Protein Diffraction Data

At the heart of HKL-3000R lies the most powerful data processing package in the world, HKL-2000. Evidence for this can be seen in the statistics of protein structure submissions to the PDB. No other processing package, commercial or public domain, comes close to matching HKL-2000 in terms of the number of PDB references.

HKL-3000R is User Friendly

HKL-3000R is a single user interface that allows for data processing and structure solution. The structure solution pipeline inherent to HKL-3000R seamlessly transfers output from one step to the next. Strategic stopping points are provided in the structure solution software to prevent the pitfalls commonly associated with black-box crystallography.

In most cases, using the default settings of the program results in a highly complete model of a macromolecule.

The software can be run in semiautomatic mode, allowing the experimenter to check and change important parameters during diffraction data processing and structure elucidation. During each step, the software provides helpful graphs and tables to analyze results and outcome. These feedback tools are valuable for optimizing parameters for subsequent steps and facilitate the structure solution process. This approach significantly accelerates the process of structure determination and, on average, minimizes the number of crystals, data sets and time required for structure solution.

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  • HKL-3000R controls the data collection instrument.
  • Data collection strategy calculation for single and multiple axes goniometers.
  • Raw image data reduction and analysis by industry standard HKL-2000
  • Structure solution pipeline uses industry standard software packages (CCP4, SHELX, ARP/wARP, Coot, etc.)
  • Communication with standard databases (PDB, SwissProt)

Graduate Student, Eric Rosenberg, using the MM007/AFC11/P200 at Yale University shares his views of working with Rigaku's scientific staff:

I collected a sulphur SAD data set on our home source using copper K-alpha radiation; these types of data sets are notorious for being difficult to process, but I recalled that a Rigaku application scientist that visited my university, Pierre, stated that he has had luck processing many in the past. I reached out to Pierre asking for some guidance in how to handle my data so that I could solve my protein’s structure, and was met with a prompt reply. Pierre was incredibly helpful with his suggestions, very polite, and even seemed personally interested in my work, following up with me a few days later. With his advice, I was able to successfully solve the structure of my protein, which I plan on publishing in my next manuscript. I’m very thankful for Pierre’s help, and for Rigaku’s customer service in general!”


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