Pasar al contenido principal

MILabs U-SPECT

MILabs U-SPECT
MILabs U-SPECT graphic

 

 

Features
  • Ultra-high SPECT resolution: 0.25 mm in-vivo, 0.12 mm ex-vivo
  • Sensitivity up to 30,000 cps/MBq
  • Dynamic whole-body SPECT
  • Multi-gated dynamic acquisitions for up to four mice
  • Cells for mice, rats, rabbits & cryogenic-cooled specimen
  • Sub-mm high-energy targeted radiotherapy applications
  • Stationary detectors for reliable, calibration-free operation
  • Upgradeable to PET/SPECT/CT and Optical/PET/SPECT/CT
Applications Bytes

Please click here for images of sample applications

In-Vivo Diagnostic X-ray CT scanner, upgradeable to Molecular CT

Ultralow dose, high-resolution, fast, adaptive X-ray CT

Ultra-high resolution SPECT:

U-SPECT is the only preclinical Single Photon Emission Computed Tomography (SPECT) system featuring stationary detectors surrounding the animal. Single-photon projections are collimated and magnified on three large NaI(Tl) detectors resulting in very high image resolutions of 0.25 mm for in-vivo imaging and 0.12 mm for an ex-vivo specimen. Stationary detectors cause no positioning imprecisions, while the absence of wear-and-tear of the detector gantry ensures unprecedented reliability and stability, virtually no downtime, and very long system life. Since SPECT images can be acquired in real-time, without detector rotation delays, U-SPECT offers fast temporal resolutions of <1 second for organ imaging and <8 seconds for whole-body mouse imaging. Depending on the installed collimator, the detection sensitivity can be as high as 30,000 cps/MBq, enabling total body SPECT of <0.10 MBq (~3 μCi). This proprietary configuration enables the acquisition of Spatial resolution: proven best in vivo SPECT resolution in the market: < 0.25 mm. Mouse (up to four simultaneously), rats, and rabbits can be imaged, and cardiac and respiratory gating eliminates cardiopulmonary artifacts.

Quantitative 3D auto-radiography option:

By scanning cryo-cooled tissue samples, such as complete organs, with a dedicated super-resolution SPECT collimator, researchers can obtain 3D autoradiography distributions at 120 micron resolution.

Theranostics: Sub-mm resolution Radiotherapy Imaging

U-SPECT can image at sub-mm resolutions photon energies up to 1 MeV. This makes direct imaging and quantitation of targeted radiotherapies (theranostics) possible for a wide range of high-energy therapeutic isotopes including ¹³¹I, and alpha particle emitters such as ²¹²Pb, ²²⁵Ac, ²¹³Bi, ²²¹Fr, ²⁰⁹At/²¹¹At, ²²³Ra

Specifications

MILabs’ proprietary focused multi-pinhole cylindrical collimators ensure an optimal sensitivity-resolution trade-off selection for any application. A wide range of collimators is available and the table below shows just a limited number of available SPECT collimators. The collimators have typically 75 pinholes and they a precisely calibrated response matrix to optimize image quality.

SPECT Collimator⁵ Purpose Resolution¹⁻⁴
 (mm)
Sensitivity
cps/MBq (%)
Sample
EXIRAD-3D 150 Special 3D autoradiography collimator with cry-cooling 0.15 ~800 (0.8%) Ex-vivo specimen
Extra Ultrahigh-resolution Mouse (XUHR-M) Extra ultrahigh-resolution total-body and focused mouse imaging <0.25 ~340 (0.04%) Mouse
General Purpose Mouse (GP-M) Geeral purpose total-body and focused mouse imaging <0.4  >13000 (1.3%) Mouse
Extra-Extra Ultrahigh-sensitivity Mouse (XXUHS-M) Extra ultralow dose total-body and focused mouse imaging <1.3 >30000 (3.0%) Mouse
General Purpose Rat and Mouse (GP-RM) General purpose for total body and focused rat and mouse imaging <1.0 >1500 (0.15%) Rat
General Purpose Medium Size Animal (GP-MSA) General purpose focused medium size animal imaging <2.0 >1200 (0.12%) Rabbit

Notes:

  1. Rod visibility Jaszczak phantoms
  2. Determined for 3/8” crystals and 99mTc
  3. For 6/8” crystals; ~1-10% lower resolution and ~7% more sensitivity
  4. Dual-head systems; ~10% lower resolution and ~33% lower sensitivity
  5. MILabs offers a wider range than shown here; dedicated collimators can be designed in collaboration with the user

MILabs U-SPECT Video