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XtaLAB Synergy Custom
  • Ultimate flexibility with customized X-ray system specifically tailored to the needs of your research. Dual ports allow for various combinations of crystallography and SAXS configurations. Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types.
  • Faster, accurate data collection due to high-speed kappa goniometer, high-flux rotating anode X-ray source, fast, low-noise X-ray detector, and highly optimized instrument control software.
  • Improve your ability to investigate small samples due to the increased flux from the rotating anode X-ray source as well as the extreme low noise of the HyPix X-ray detectors. Noise-free images mean you can count longer for weakly diffracting crystals without a loss in data quality arising from detector noise.
  • Screen crystals in situ with optional XtalCheck crystallization plate screening device.
  • Enhance your ability to resolve large unit cells, twins or incommensurate lattices when you select the optional motorized variable beam slit in order to alter divergence to adapt the source to your sample’s requirements.

Customized Single Crystal Diffraction System With Microfocus Rotating Anode Generator

X-ray crystal structure determination and SAXS for macromolecules

XtaLAB Synergy Custom

One of the advantages of Rigaku's rotating anode X-ray generators is the ability to utilize both ports of the generator simultaneously. This might involve having two single crystal goniometers mounted on the generator or it might involve having one goniometer and a sample changing robot on one port and a BioSAX-2000nano small angle scattering Kratky camera mounted on the other port. In order to accommodate the various configurations that a researcher might envision, Rigaku offers the XtaLAB Synergy Custom, a system that can be configured with either a MicroMax-007 HF microfocus rotating anode source or the highest-flux in-house X-ray source, the FR-X. Additionally, the XtaLAB Synergy Custom comes in a specially designed enclosure with your choice of table size to accommodate accessory equipment, such as an ACTOR robotic system or a microscope close to the goniometer. Thus, the versatility offered by the XtaLAB Synergy Custom system provides the most flexibility possible for your structural biology program.

HPC direct detection X-ray detector

XtaLAB Synergy Custom systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, such as the HyPix-6000HE, the HyPix-Arc 150° or the Dectris EIGER 4M. HPC detectors are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB Synergy Custom systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments.

CrysAlisPro v40

The XtaLAB Synergy Custom comes complete with CrysAlisPro, our user-inspired data collection and data processing software for single crystal analysis. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control. Of particular interest to protein crystallographers is the ability to operate CrysAlisPro either in a protein or small molecule dedicated workflow. Popular third party protein data processing packages can easily process diffraction data if desired. CrysAlisPro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution. Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible.


If a XtaLAB Synergy Custom diffractometer is to be shared with small molecule crystallographers, AutoChem is included as the ultimate productivity tool for small molecule chemists, offering fast, fully automatic structure solution and refinement during data collection. Developed in collaboration with OlexSys Ltd (Durham University, UK), AutoChem works in conjunction with Olex² where more advanced structure solution and refinement functionality exists. AutoChem is seamlessly integrated within CrysAlisPro, and forms an integral part of our ‘What is this?’ feature. The ‘What is this?’ feature gives you structures quickly and ensures you are not wasting time collecting full datasets on known samples or starting materials. It is an alternative pre-experiment option, which is used to plan your full data collections.

Product name XtaLAB Synergy Custom
Core attributes X-ray diffractometer with dual-port rotating anode X-ray source and HPC detector
Detectors HyPix-6000HE, the large theta coverage HyPix-Arc 150° or the Dectris EIGER 4M.
X-ray source MicroMax-007 HF microfocus rotating anode source or the highest flux in-house X-ray source, the FR-X (Mo, Cu, or Cr).
Goniometer Fast kappa geometry goniometer that allows data collection scan speeds of up to 10°/sec. 
Accessories Oxford Cryostream 800, Oxford Cobra, XtalCheck-S, ACTOR robotic sample changer.
Computer External PC, MS Windows® OS
Core dimensions Varies with configuration
Mass Varies with configuration
Power requirements Varies with configuration


The following applications are relevant to this product