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XtaLAB Synergy-DW VHF
  • Faster, accurate data collection due to high-speed kappa goniometer, high-flux rotating anode X-ray source, fast, low-noise X-ray detector, and highly optimized instrument control software.
  • Enhanced experimental versatility with two switchable wavelengths (the following combinations are available: Mo/Cu, Cu/Cr, Cu/Co, Cu/Ag, and Ag/Mo; only Mo and Cu optics are available with VHF style optics).
  • Enhance your ability to resolve large unit cells, twins or incommensurate lattices when you select the optional motorized variable beam slit in order to alter divergence to adapt the source to your sample’s requirements.
  • Improve your ability to investigate small samples due to the increased flux from the rotating anode X-ray source as well as the extreme low noise of the HyPix X-ray detectors. Noise-free images mean you can count longer for weakly diffracting crystals without a loss in data quality arising from detector noise.
  • Highest level of user safety with multiply redundant electromechanical safety circuits built into the ergonomically designed radiation enclosure.
  • Minimize your downtime by utilizing built-in online diagnostics and troubleshooting to diagnose and fix almost all problems without a site visit. Even though two wavelengths are available, only one X-ray source is used.

Dual-Wavelength Rotating Anode X-Ray Diffractometer With HPC X-Ray Detector

A multi-functional single crystal X-ray diffractometer for a wide range of crystallographic applications

XtaLAB Synergy-DW

One source with two high-flux wavelengths is the foundation of the revolutionary XtaLAB Synergy-DW VHF single crystal X-ray diffractometer. It combines the increased flux of a rotating anode X-ray source with the flexibility of two different wavelengths, making it ideal for laboratories exploring a wide range of research interests. It is the perfect diffractometer for a core facility where protein crystallography and small molecule crystallography are both practiced.


The XtaLAB Synergy-DW VHF diffractometer is based on the proven, low-maintenance MicroMax-007 HF microfocus rotating anode X-ray generator. The target is constructed with two different X-ray source materials (the following combinations are available: Mo/Cu, Cu/Cr, Cu/Co, Cu/Ag, and Ag/Mo; only Mo and Cu optics are available with VHF style optics) and is coupled with an auto-switching dual-wavelength optic. Two wavelengths of X-ray radiation are available at the click of a button. Rounding out the XtaLAB Synergy-DW VHF configuration is the fast and efficient four-circle kappa goniometer, which is compatible with Rigaku’s Hybrid Photon Counting (HPC) X-ray detector, the HyPix-6000HE (or optionally the HyPix-Arc 150° or Dectris EIGER 4M) with extremely low readout noise, no dark noise and high dynamic range, and the CrysAlisPro diffraction software package with sophisticated algorithms to tie the hardware together to minimize the time it takes to measure data from protein crystals.

HPC direct detection X-ray detector

XtaLAB Synergy-DW VHF systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, which are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB Synergy DW systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments.


The PhotonJet-DW comes from the same pedigree as the MicroMax-007 HF, of which there are well over 1000 units in use around the world. The PhotonJet-DW X-ray source applies the lessons learned over the development and lifetime of the MicroMax™-007 rotating anode to produce a new generation, high-performance rotating anode source. With the source mounted directly onto the goniometer, the XtaLAB Synergy-DW VHF provides a stable and robust solution that ensures consistently high performance. Dual-wavelength confocal optics designed by Rigaku Innovative Technologies offer high brilliance and an optional continuously variable slit assembly gives high brilliance or low divergence as needed to cater to any sample. It only takes 5 minutes to switch between wavelengths and it is all done under computer control.

Proven Reliability

The PhotonJet-R source was designed with reliability in mind. Clever Rigaku engineering makes filament changes easy, like swapping a printer cartridge, with no need to realign the source each time. Scheduled maintenance involves one annual visit from a Rigaku engineer, as with all XtaLAB Synergy diffractometers, and typically takes 1-2 days. With the anode exchange program, you get the benefit of rotating anode power with the convenience of sealed tubes.

Beam Conditioning

Where overlapping peaks are a concern, e.g. large unit cells, proteins, twinned or incommensurate, high beam divergence is undesirable. On PhotonJet sources, a software controlled, motorized variable beam slit is available as an option to alter divergence to adapt the source to your sample’s requirements. For those samples where intensity matters most, the slit can be fully opened giving the highest flux. For those where peak sharpness and overlap are factors, the beam can be limited to a divergence anywhere between 1 to 10 mrad.

CrysAlisPro v40

The XtaLAB Synergy-DW VHF comes complete with CrysAlisPro, our user-inspired data collection and data processing software for single crystal analysis. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control. Of particular interest to protein crystallographers is the ability to operate CrysAlisPro either in a protein or small molecule dedicated workflow. Popular third-party protein data processing packages can easily process diffraction data if desired. CrysAlisPro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution. Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible.


If a XtaLAB Synergy-DW VHF diffractometer diffractometer is to be shared with small molecule crystallographers, AutoChem is included as the ultimate productivity tool for small molecule chemists, offering fast, fully automatic structure solution and refinement during data collection. Developed in collaboration with OlexSys Ltd (Durham University, UK), AutoChem works in conjunction with Olex² where more advanced structure solution and refinement functionality exists. AutoChem is seamlessly integrated within CrysAlisPro, and forms an integral part of our ‘What is this?’ feature. The ‘What is this?’ feature gives you structures quickly and ensures you are not wasting time collecting full datasets on known samples or starting materials. It is an alternative pre-experiment option, which is used to plan your full data collections.

Product name XtaLAB Synergy-DW VHF
Core attributes Dual wavelength rotating anode X-ray source diffractometer with hybrid pixel array detector and kappa goniometer
Detectors HyPix-6000HE, the large theta coverage HyPix-Arc 150°,  or Dectris EIGER 4M
X-ray source PhotonJet-R X-ray source with a target that is constructed with two different X-ray source materials (the following combinations are available: Mo/Cu, Cu/Cr, Cu/Co, Cu/Ag, and Ag/Mo; only Mo and Cu optics are available with VHF style optics) and is coupled with an auto-switching dual-wavelength optic.
Goniometer Fast kappa geometry goniometer that allows data collection scan speeds of up to 10°/sec.
Accessories Oxford Cryostream 800, Oxford Cobra, XtalCheck-S
Computer External PC, MS Windows® OS, CrysAlisPro Software
Core dimensions 1300 (W) x 1875 (H) x 850 (D) (mm)
Mass 600 kg (core unit)
Power requirements 1Ø, 200-230 V, 20 A