nano3DX

nano3DX
X-ray microscope for high resolution - imaging X-ray microscope for high resolution - imaging X-ray microscope for high resolution - imaging X-ray microscope for high resolution - imaging X-ray microscope for high resolution - imaging X-ray microscope for high resolution - imaging
Features
  • True submicron resolution by parallel beam geometry coupled with an ultra-thin scintillator and optical lens magnification
  • High-contrast for low-density materials by selectable characteristic radiations (Cr 5.4 keV, Cu 8 keV, Mo 17 keV) additional to bremsstrahlung radiation from W target
  • Easy radiation selection by the dual-wavelength X-ray source
  • Fast scans by the MicroMax-007 high-power (1200 W) rotating anode X-ray source and sCMOS detector

 

An Insight to the nano3DX - X-Ray Microscope

X-ray microscope

True submicron high-contrast X-ray computed tomography

Learn More  
Features | Specifications | Video | Applications | Events | Webinars | Publications
 

Rigaku nano3DX represents the state of the art in laboratory-based nanoscale X-ray imaging. With up to 100X the X-ray flux of conventional microfocus X-ray sources, the nano3DX provides fast, true sub-micron 2D, 3D, and 4D measurements for a wide range of sample types.

High-resolution: High-quality CT images are obtained at submicron resolution by utilizing parallel beam X-ray geometry coupled with an ultra-thin scintillator and optical lens magnification.

High-contrast for lighter materials: The contrast in samples with low-density (organics, composites, ceramics, polymers, light metals, and minerals) is enhanced by utilizing high-power (1200 W) quasi-monochromatic radiations from 5.4 keV to 17 keV.

High-speed: A combination of the high-flux X-ray source and an sCMOS detector enhances sample throughput and enables high-resolution 4D measurements for time-resolved in-situ experiments.

Specifications
Product name nano3DX
Benefit True submicron high-contrast X-ray computed tomography
Technology X-ray computed tomography
X-ray generator MicroMax-007 HF rotating anode X-ray generator
Tube voltage 20 to 60 kV
Tube current up to 30 mA
Target Cr, Cu, Mo, and W
Detector sCMOS
Field of view Maximum 10 mm
Resolution Maximum 325 nm

nano3DX videos

Application Bytes

Webinars - X-ray Computed Tomography for Materials Science

X-ray Computed Tomography for Materials Science 1: Introduction

Aya Takase
An introduction to the X-ray computed tomography (CT) technique. Designed to show how X-ray CT works and how it can be applied to scientific research. It will include an introduction to the technique, instrumentation and application examples.
Watch this webinar on demand

X-ray Computed Tomography for Materials Science 2: Data Analysis

Aya Takase
An overview of X-ray CT data analysis techniques starting with basic image processing and leading to traditional segmentation, machine learning based segmentation and quantitative analysis. A number of commonly used data analysis and visualization programs will be discussed and demonstrated to help beginners to get an idea of where to start and select the right analysis tool for their needs
Watch this webinar on demand

X-ray Computed Tomography for Materials Science 3: Food and Pharmaceutical Applications

Aya Takase
A number of X-ray CT application examples in the food and pharmaceutical industries will be discussed. Examples to include the analyses of cracks and aggregation inside tablets, tablet and drug particle coating thicknesses, air pocket size distributions in food and sugar coating thicknesses of candies.
Watch this webinar on demand

X-ray Computed Tomography for Materials Science 4: Foams and Composites Applications

Aya Takase
A number of X-ray CT application examples of foams and composite materials will be discussed. Examples to include the analysis of foam porosity, cell size, and cell wall thicknesses as well as void distribution and fiber orientation in composite materials.
Watch this webinar on demand

X-ray Computed Tomography for Materials & Life Science 5: Plant Science Applications

Angela Criswell
A number of X-ray CT application examples for plants and seeds will be discussed. Examples to include the non-destructive characterization of plant traits for ripening fruit, seeds and root systems. Additionally, analysis of cell wall thicknesses and void distribution among different seed varieties will be presented.
Watch this webinar on demand

X-ray Computed Tomography for Materials and Life Science 6: Geology Applications

Aya Takase
A number of X-ray CT application examples of geological samples will be discussed. Examples include the analysis of cracks, pores, inclusions, and phase quantification of rocks and drill cores. We will introduce available resources for pore network analysis that can be applied to rock CT scans.
Watch this webinar on demand

X-ray Computed Tomography for Materials and Life Science 7: Life Science Applications

Angela Criswell
A 3D look at the structures of a reptile, insects, and a mouse, including their stained organs. In the newest episode of the webinar series “X-ray Computed tomography for Materials & Life Science,” we will discuss how to deal with unique challenges in life science sample preparation and introduce some quantitative analyses.
Watch this webinar on demand

X-Ray Computed Tomography for Materials & Life Sciences 8: Metrology Applications

Aya Takase
Basics of metrology analysis and a number of X-ray CT application examples will be discussed. Examples include size and shape measurements of metal and plastic parts, tolerancing evaluation, comparison of nominal (CAD) and actual (CT) or a golden standard and a test subject. We will also introduce available resources to learn more about X-ray CT metrology.
Watch this webinar on demand

X-ray Computed Tomography for Soft Materials

Angela Criswell

This webinar will discuss basics of X-ray computed tomography and how to apply X-ray CT methods to soft materials. Additionally, we will show 3D imaging results for pharmaceuticals, foams, composites and other soft material.

We invite you to view this short video about the Rigaku nano3DX X-ray microscope for microtomography of large samples at high resolution in advance of the webinar.

Watch this webinar on demand

X-ray Computed Tomography for Materials & Life Science 9: 4D and in-situ applications

Aya Takase
In this webinar, we will discuss the keys to successful 4D and in-situ X-ray CT measurements and how to plan experiments.
Watch this webinar on demand

X-ray CT Publications

Our first CT project

Morio ONOE, Jing Wen TSAO and Hiroaki YAMADA, Hiroshi NAKAMURA, Jin KOGURE and Hiromi KAWAMURA, M. Y. (1984). COMPUTED TOMOGRAPHY FOR MEASURING THE ANNUAL RINGS OF A LIVE TREE. Nuclear Instruments and Methods in Physics Research, 221, 213-220. https://www.sciencedirect.com/science/article/pii/0167508784902023 

  1. Joseph P. Neilly, Leilei Yin, Sarah-Ellen Leonard, Paul J.A. Kenis, Gerald D. Danzer, Ashtamurthy S. Pawate (2019) Quantitative Measures of Crystalline Fenofibrate in Amorphous Solid Dispersion Formulations by X-Ray Microscopy, Journal of Pharmaceutical Sciences, 109(10), 3078-3085 https://www.sciencedirect.com/science/article/pii/S0022354920303683
  2. Carolina Oliver-Urrutia, Raúl Rosales Ibañez, Miriam V. Flores-Merino, Lucy Vojtova, Jakub Salplachta, Ladislav Čelko, Jozef Kaiser, and Edgar B. Montufar (2021). Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells. Materials 14, 227. https://www.mdpi.com/1996-1944/14/1/227/htm
  3. Tomáš Sedlačík, Takayuki Nonoyama, Honglei Guo, Ryuji Kiyama, Tasuku Nakajima, Yoshihiro Takeda, Takayuki Kurokawa, and Jian Ping Gong (2020). Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation. Chem. Mater. Published online18 September 2020. https://pubs.acs.org/doi/abs/10.1021/acs.chemmater.0c02911
  4. Nanako Sakata, Yoshihiro Takeda, Masaru Kotera, Yasuhito Suzuki, and Akikazu Matsumoto. (2020). Interfacial Structure Control and Three-Dimensional X-ray Imaging of an Epoxy Monolith Bonding System with Surface Modification. Langmuir, 36, 37, 10923–10932. https://pubs.acs.org/doi/10.1021/acs.langmuir.0c01481
  5. Kenji Ohta , Tatsuya Wakamatsu, Manabu Kodama , Katsuyuki Kawamura, and Shuichiro Hirai. Laboratory-based x-ray computed tomography for 3D imaging of samples in a diamond anvil cell in situ at high pressures. Rev. Sci. 91, 091101. https://aip.scitation.org/doi/pdf/10.1063/5.0014486
  6. Fukami, T., Koide, T., Hisada, H., Inoue, M., Yamamoto, Y., Suzuki, T., & Tomono, K. (2016). Pharmaceutical evaluation of atorvastatin calcium tablets available on the Internet: A preliminary investigation of substandard medicines in Japan. Journal of Drug Delivery Science and Technology, 31, 35-40. https://doi.org/10.1016/j.jddst.2015.11.006 
  7. Kalasova, D., Zikmund, T., Pina, L., Takeda, Y., Horvath, M., Omote, K., & Kaiser, J. (2019). Characterization of a laboratory-based X-ray computed nanotomography system for propagation-based method of phase contrast imaging. IEEE Transactions on Instrumentation and Measurement, PP(c), 1-1. https://doi.org/10.1109/tim.2019.2910338 
  8. Kunishima, N., Takeda, Y., Hirose, R., Kalasová, D., Šalplachta, J., & Omote, K. (2020). Visualization of internal 3D structure of small live seed on germination by laboratory-based X-ray microscopy with phase contrast computed tomography. Plant Methods, 16(1), 1-10. https://doi.org/10.1186/s13007-020-0557-y 
  9. Zhang, S., Byrnes, A. P., Jankovic, J., & Neilly, J. (2019). Management, Analysis, and Simulation of Micrographs with Cloud Computing. Microscopy Today, 27(2), 26-33. https://doi.org/10.1017/s1551929519000026 
  10. Kalasová, D., Zikmund, T., Pína, L., Horváth, M., & Kaiser, J. (2016). Phase contrast tomographic imaging of polymer composites. 2020, 2020. http://ctlab.ceitec.cz/files/252/165.pdf 
  11. Kalasova, D., Pavlinakova, V., Zikmund, T., Vojtova, L., & Kaiser, J. (2018). Correlation of X-ray Computed Nanotomography and Scanning Electron Microscopy Imaging of Collagen Scaffolds. Microscopy and Microanalysis, 24(S2), 104-105. https://doi.org/10.1017/s1431927618012904 
  12. Hisada, K., Matsuoka, M., Tabata, I., Hirogaki, K., & Hori, T. (2013). Two-step radical grafting onto polypropylene fiber initiated by active species prepared through the irradiation of electron beam. Journal of Photopolymer Science and Technology, 26(2), 277-282. https://doi.org/10.2494/photopolymer.26.277 
  13. Sekita, A., Matsugaki, A., & Nakano, T. (2017). Disruption of collagen/apatite alignment impairs bone mechanical function in osteoblastic metastasis induced by prostate cancer. Bone, 97, 83-93. https://doi.org/10.1016/j.bone.2017.01.004 
  14. Nanako Sakata, Yoshihiro Takeda, Masaru Kotera, Yasuhito Suzuki, and A. M. (2020). Non‐destructive 3D X‐ray Imaging of Internal and Interfacial Structure of Epoxy Monolith and Strength Control by Surface Modification for the Monolith Bonding System. Langmuir. https://pubs.acs.org/doi/abs/10.1021/acs.langmuir.0c01481 
  15. Tomáš Sedlačík, Takayuki Nonoyama, Honglei Guo, Tasuku Nakajima, Yoshihiro Takeda, Takayuki Kurokawa, J. P. G. (2020). Tough Double- and Triple- Network Supermacroporous Hydrogels through Repeated Cryogelation. ACS Publications. https://pubs.acs.org/doi/abs/10.1021/acs.chemmater.0c02911 
  16. Kakio, T., Yoshida, N., Macha, S., Moriguchi, K., Hiroshima, T., Ikeda, Y., Kimura, K. (2017). Classification and visualization of physical and chemical properties of falsified medicines with handheld Raman spectroscopy and X-Ray computed tomography. American Journal of Tropical Medicine and Hygiene, 97(3), 684-689. https://doi.org/10.4269/ajtmh.16-0971 
  17. Takase, A., McNulty, T., & Fitzgibbons, T. (2018). Foam Porosity Calculation by X-Ray Computed Tomography and Errors Caused by Insufficient Resolution. Microscopy and Microanalysis, 24(S2), 546-547. https://doi.org/10.1017/s1431927618014927 
  18. Omote, K., Iwata, T., Takeda, Y., & Ferrara, J. D. (2017). Investigation for fuel-cell structures with multi-scale X-ray analysis. Rigaku Journal, 33(2), 8-13. https://www.semanticscholar.org/paper/Investigation-for-fuel-cell-structures-with-X-ray-Omote-Iwata/78e57af8fa13252533eabb7d5e5a32ceadac9eaa?p2df 
  19. Watanabe, M., Takeda, Y., Maruyama, T., Ikeda, J., Kawai, M., & Mitsumata, T. (2019). Chain structure in a cross-linked polyurethane magnetic elastomer under a magnetic field. International Journal of Molecular Sciences, 20(12). https://doi.org/10.3390/ijms20122879 
  20. Kunishima, N., Takeda, Y., Hirose, R., Kalasová, D., Šalplachta, J., & Omote, K. (2020). Visualization of internal 3D structure of small live seed on germination by laboratory-based X-ray microscopy with phase contrast computed tomography. Plant Methods, 16(1), 1-10. https://doi.org/10.1186/s13007-020-0557-y 
  21. Kalasova, D., Zikmund, T., Pina, L., Takeda, Y., Horvath, M., Omote, K., & Kaiser, J. (2020). Characterization of a laboratory-based x-ray computed nanotomography system for propagation-based method of phase contrast imaging. IEEE Transactions on Instrumentation and Measurement, 69(4), 1170-1178. https://doi.org/10.1109/TIM.2019.2910338 
  22. Akitomo, F., Sasabe, T., Yoshida, T., Naito, H., Kawamura, K., & Hirai, S. (2019). Investigation of effects of high temperature and pressure on a polymer electrolyte fuel cell with polarization analysis and X-ray imaging of liquid water. Journal of Power Sources, 431(February), 205-209. https://doi.org/10.1016/j.jpowsour.2019.04.115 
  23. Watanabe, M., Takeda, Y., Maruyama, T., Ikeda, J., Kawai, M., & Mitsumata, T. (2019). Chain structure in a cross-linked polyurethane magnetic elastomer under a magnetic field. International Journal of Molecular Sciences, 20(12). https://doi.org/10.3390/ijms20122879 
  24. Kalasová, D., Zikmund, T., Mancini, L., Jaroš, J., Tesařová, M., Kaucká, M., Kaiser, J. (2016). Industrial Tomography System for Answering Biological Issues: Development of the Mouse Embryo Face. 6th Conference on Industrial Computed Tomography (ICT 2016), (iCT), 1-9. https://www.ndt.net/article/ctc2016/papers/ICT2016_paper_id37.pdf 
  25. Tanaka, K., Yamada, T., Moriito, K., & Katayama, T. (2016). The effect of molding pressure on the mechanical properties of CFRTP using paper-type intermediate material. High Performance and Optimum Design of Structures and Materials II, 1(Hpsm), 307-315. https://doi.org/10.2495/hpsm160281 
  26. Watanabe, M., Ikeda, J., Takeda, Y., Kawai, M., & Mitsumata, T. (2018). Effect of Sonication Time on Magnetorheological Effect for Monomodal Magnetic Elastomers. Gels, 4(2), 49. https://doi.org/10.3390/gels4020049 
  27. Fukami, T., Koide, T., Hisada, H., Inoue, M., Yamamoto, Y., Suzuki, T., & Tomono, K. (2016). Pharmaceutical evaluation of atorvastatin calcium tablets available on the Internet: A preliminary investigation of substandard medicines in Japan. Journal of Drug Delivery Science and Technology, 31, 35-40. https://doi.org/10.1016/j.jddst.2015.11.006 
  28. Eiichi Yamamoto, Yoshihiro Takeda, Daisuke Ando, Tatsuo Koide, Yuta Amano, Shingo Miyazaki, Tamaki Miyazaki, Ken-ichi Izutsu, Hideko Kanazawa, and Yukihiro Goda. (2021). Discrimination of ranitidine hydrochloride crystals using X-ray micro-computed tomography for the evaluation of three-dimensional spatial distribution in solid dosage forms. Int. J. Pharm. Available online 28 June 2021, 120834 https://doi.org/10.1016/j.ijpharm.2021.120834
  29. Naoki Kunishima, Raita Hirose, Yoshihiro Takeda, Koichiro Ito, Kengo Furuichi & Kazuhiko Omote. (2022). Nondestructive cellular-level 3D observation of mouse kidney using laboratory-based X-ray microscopy with paraffin-mediated contrast enhancement. Scientific Reports volume 12, Available online 10 June 2022. https://doi.org/10.1038/s41598-022-13394-9

  1. Aung, W., Jin, Z. H., Furukawa, T., Claron, M., Boturyn, D., Sogawa, C., … Saga, T. (2013). Micro-positron emission tomography/contrast-enhanced computed tomography imaging of orthotopic pancreatic tumor-bearing mice using the αvβ3 integrin tracer 64Cu-labeled cyclam-RAFT-c(-RGDfK-)4. Molecular Imaging, 12(6), 376-387. https://doi.org/10.2310/7290.2013.00054 
  2. Arai, Y., Yamada, A., Ninomiya, T., Kato, T., & Masuda, Y. (2005). Micro-computed tomography newly developed for in vivo small animal imaging. Oral Radiology, 21(1), 14-18. https://doi.org/10.1007/s11282-005-0024-5 
  3. Reedy, C. L. (2020). 3D Documentation and Analysis of Porosity in Deteriorated Historic Brick. Studies in Conservation, 0(0), 1-4. https://doi.org/10.1080/00393630.2020.1752426 
  4. Iikubo, M., Nishioka, T., Okura, S., Kobayashi, K., Sano, T., Katsumata, A., … Sasano, T. (2016). Influence of voxel size and scan field of view on fracture-like artifacts from gutta-percha obturated endodontically treated teeth on cone-beam computed tomography images. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 122(5), 631-637. https://doi.org/10.1016/j.oooo.2016.07.014 
  5. Benjamin M. Davis, Glen F. Rall, M. J. S. (2017). HHS Public Access. Physiology & Behavior, 176(1), 139-148. https://doi.org/10.1016/j.physbeh.2017.03.040 
  6. Bolmin, O., Wei, L., Hazel, A. M., Dunn, A. C., Wissa, A., & Alleyne, M. (2019). Latching of the click beetle (Coleoptera: Elateridae) thoracic hinge enabled by the morphology and mechanics of conformal structures. Journal of Experimental Biology, 222(12). https://doi.org/10.1242/jeb.196683 
  7. Kameoka, S., Matsumoto, K., Kai, Y., Yonehara, Y., Arai, Y., & Honda, K. (2010). Establishment of temporomandibular joint puncture technique in rats using in vivo micro-computed tomography (R-mCT®). Dentomaxillofacial Radiology, 39(7), 441-445. https://doi.org/10.1259/dmfr/37174063 

  1. Hagen, C. K., Vittoria, F. A., Morgó, O. R. I., Endrizzi, M., & Olivo, A. (2020). Cycloidal Computed Tomography. Physical Review Applied, 14(1), 1. https://doi.org/10.1103/PhysRevApplied.14.014069 
  2. Diemoz, P. C., Hagen, C. K., Endrizzi, M., Minuti, M., Bellazzini, R., Urbani, L., … Olivo, A. (2017). Single-Shot X-Ray Phase-Contrast Computed Tomography with Nonmicrofocal Laboratory Sources. Physical Review Applied, 7(4), 1-6. https://doi.org/10.1103/PhysRevApplied.7.044029 
  3. Hagen, C. K., Endrizzi, M., Diemoz, P. C., & Olivo, A. (2016). Reverse projection retrieval in edge illumination x-ray phase contrast computed tomography. Journal of Physics D: Applied Physics, 49(25). https://doi.org/10.1088/0022-3727/49/25/255501 
  4. Zamir, A., Endrizzi, M., Hagen, C. K., Vittoria, F. A., Urbani, L., De Coppi, P., & Olivo, A. (2016). Robust phase retrieval for high resolution edge illumination x-ray phase-contrast computed tomography in non-ideal environments. Scientific Reports, 6(August), 1-9. https://doi.org/10.1038/srep31197