Rigaku has developed a new series of single crystal diffractometers that address a wide range of sample types, from small molecules to MOFs, to biological macromolecules. The key component that is common for this series of diffractometers is the use of an HPAD (hybrid pixel array detector), a technology that produces an almost perfect detector and greatly expands the capabilities of a single crystal diffractometer in terms of speed of data acquisition and more accurate measurement of weak data. The standard detector in the XtaLAB PRO series is the PILATUS 200K, a detector that is well proven in the field and based on the same technology adopted by synchrotron beamlines around the world. The outstanding characteristics of these detectors ensure that every XtaLAB PRO diffractometer will perform to produce the best data possible for the X-ray source selected.