XtaLAB Synergy-ED
Fully Integrated Electron Diffractometer
A system any X-ray crystallographer will find intuitive to operate
XtaLAB Synergy-ED is a new and fully integrated electron diffractometer, creating a seamless workflow from data collection to structure determination of three-dimensional molecular structures. The key feature of this product is that it provides researchers an integrated platform enabling easy access to electron crystallography. The XtaLAB Synergy-ED is a system any X-ray crystallographer will find intuitive to operate without having to become an expert in electron microscopy.
XtaLAB Synergy-ED Overview
The XtaLAB Synergy-ED is the result of an innovative collaboration to synergistically combine our core technologies: Rigaku’s high-speed, high-sensitivity photon-counting detector (HyPix-ED) and state-of-the-art instrument control and single crystal analysis software platform (CrysAlisPro for ED), and JEOL’s long-term expertise and market leadership in designing and producing transmission electron microscopes.
The XtaLAB Synergy-ED was designed to address the increasing need to investigate smaller and smaller samples in structural research. With X-ray crystallography, the smallest possible crystal dimension is 1 micron, and only then when utilizing the brightest X-ray sources and noise free detectors. However, in recent years, there has been an increasing need for the structure analysis of substances that only form microcrystals, crystals that are only a few hundred nanometers or less in size. In recent years, a new analytical method, MicroED, has been developed that uses electron diffraction on a TEM electron microscope to measure 3D molecular structures from nanocrystalline materials. Researchers developing this technique have relied on customized electron microscopes and a combination of microscopy software for measuring diffraction data, and public domain X-ray crystallography software for data processing and structure determination. Switching a microscope configuration between imaging and diffraction can be time-consuming, making the sharing of an instrument sometimes difficult.
To address these issues, Rigaku and JEOL started a collaboration to develop a dedicated single crystal structure analysis platform for nanocrystals utilizing key technologies from both companies. The result is the XtaLAB Synergy-ED, a dedicated electron diffractometer that is operated by the same control software that is used to run Rigaku’s X-ray diffractometers and includes a complete integrated pipeline from sample selection and diffraction measurement to data processing and structure solution. This instrument can easily be installed in an existing X-ray crystallography facility, where researchers and students will be able to easily master the MicroED technique since the software workflow is the same as for an X-ray diffractometer. Having such an instrument installed in an X-ray facility immediately provides structure determination for materials that only form nanocrystals.
XtaLAB Synergy-ED Features
XtaLAB Synergy-ED Videos
XtaLAB Synergy-ED Specifications
Technique | Single crystal electron diffraction | |
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Attributes | Dedicated electron diffractometer with hybrid pixel array detector, rotation axis, and CrysAlisPro-ED, a complete integrated software platform. | |
Detector | High-speed, high-sensitivity hybrid pixel array detector, HyPix-ED | |
Source | Acceleration up to 200 kV | |
Goniometer | Single rotation axis | |
Accessories | Various low temperature devices | |
Computer | External PC, MS Windows OS |
XtaLAB Synergy-ED Application Notes
XtaLAB Synergy-ED Resources
Webinars
3D-ED in Pharmaceutical Compounds: Can we Measure Everything? | Watch the Recording |
XtaLAB Synergy-ED: Single Crystal Structures from Powders | Watch the Recording |
XtaLAB Synergy-ED Progress and Latest Results | Watch the Recording |
MicroED: An Update from the Rigaku/JEOL Collaboration | Watch the Recording |
Rigaku Journal articles
Structure Analysis of Nano-Size Crystals by the XtaLAB Synergy-ED: An Integrated Platform for 3D ED/MicroED | Read the Article |
Breaking the 1-μm barrier with the electron diffractometer XtaLAB Synergy-ED | Read the Article |
XtaLAB Synergy-ED: An Electron Diffractometer for Routine Single Crystal Diffraction Studies | Read the Article |
Publications
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