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XtaLAB Synergy-DW
Benefits
  • Faster, accurate data collection due to high-speed kappa goniometer, high-flux rotating anode X-ray source, fast, low-noise X-ray detector, and highly optimized instrument control software.
  • Enhanced experimental versatility with two switchable wavelengths (the following combinations are available: Mo/Cu, Cu/Cr, Cu/Co, and Ag/Mo).
  • Enhance your ability to resolve large unit cells, twins or incommensurate lattices when you select the optional motorized variable beam slit in order to alter divergence to adapt the source to your sample’s requirements.
  • Improve your ability to investigate small samples due to the increased flux from the rotating anode X-ray source as well as the extreme low noise of the HyPix X-ray detectors. Noise-free images mean you can count longer for weakly diffracting crystals without a loss in data quality arising from detector noise.
  • Highest level of user safety with multiply redundant electromechanical safety circuits built into the ergonomically designed radiation enclosure.
  • Minimize your downtime by utilizing built-in online diagnostics and troubleshooting to diagnose and fix almost all problems without a site visit. Even though two wavelengths are available, only one X-ray source is used.

Dual-Wavelength Rotating Anode X-Ray Diffractometer With HPC X-Ray Detector

A multi-functional single crystal X-ray diffractometer for a wide range of crystallographic applications

XtaLAB Synergy-DW

One source with two high-flux wavelengths is the foundation of the revolutionary XtaLAB Synergy-DW single crystal X-ray diffractometer. It combines the increased flux of a rotating anode X-ray source with the flexibility of two different wavelengths, making it ideal for laboratories exploring a wide range of research interests. It is the perfect diffractometer for a core facility where protein crystallography and small molecule crystallography are both practiced.

Configuration

The XtaLAB Synergy-DW diffractometer is based on the proven, low-maintenance MicroMax-007 HF microfocus rotating anode X-ray generator. The target is constructed with two different X-ray source materials (the following combinations are available: Mo/Cu, Cu/Cr, Cu/Co, and Ag/Mo) and is coupled with an auto-switching dual-wavelength optic. Two wavelengths of X-ray radiation are available at the click of a button. Rounding out the XtaLAB Synergy-DW configuration is the fast and efficient four-circle kappa goniometer, which is compatible with Rigaku’s Hybrid Photon Counting (HPC) X-ray detector, the HyPix-6000HE (or optionally the HyPix-Arc 150° or Dectris EIGER 4M) with extremely low readout noise, no dark noise and high dynamic range, and the CrysAlisPro diffraction software package with sophisticated algorithms to tie the hardware together to minimize the time it takes to measure data from protein crystals.

HPC direct detection X-ray detector

XtaLAB Synergy-DW systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, which are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB Synergy DW systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments.

PhotonJet-DW

The PhotonJet-DW comes from the same pedigree as the MicroMax-007 HF, of which there are well over 1000 units in use around the world. The PhotonJet-DW X-ray source applies the lessons learned over the development and lifetime of the MicroMax™-007 rotating anode to produce a new generation, high-performance rotating anode source. With the source mounted directly onto the goniometer, the XtaLAB Synergy-DW provides a stable and robust solution that ensures consistently high performance. Dual-wavelength confocal optics designed by Rigaku Innovative Technologies offer high brilliance and an optional continuously variable slit assembly gives high brilliance or low divergence as needed to cater to any sample. It only takes 5 minutes to switch between wavelengths and it is all done under computer control.

Proven Reliability

The PhotonJet-R source was designed with reliability in mind. Clever Rigaku engineering makes filament changes easy, like swapping a printer cartridge, with no need to realign the source each time. Scheduled maintenance involves one annual visit from a Rigaku engineer, as with all XtaLAB Synergy diffractometers, and typically takes 1-2 days. With the anode exchange program, you get the benefit of rotating anode power with the convenience of sealed tubes.

Beam Conditioning

Where overlapping peaks are a concern, e.g. large unit cells, proteins, twinned or incommensurate, high beam divergence is undesirable. On PhotonJet sources, a software controlled, motorized variable beam slit is available as an option to alter divergence to adapt the source to your sample’s requirements. For those samples where intensity matters most, the slit can be fully opened giving the highest flux. For those where peak sharpness and overlap are factors, the beam can be limited to a divergence anywhere between 1 to 10 mrad.

CrysAlisPro v40

The XtaLAB Synergy-DW comes complete with CrysAlisPro, our user-inspired data collection and data processing software for single crystal analysis. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control. Of particular interest to protein crystallographers is the ability to operate CrysAlisPro either in a protein or small molecule dedicated workflow. Popular third-party protein data processing packages can easily process diffraction data if desired. CrysAlisPro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution. Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible.

AutoChem

If a XtaLAB Synergy-DW diffractometer diffractometer is to be shared with small molecule crystallographers, AutoChem is included as the ultimate productivity tool for small molecule chemists, offering fast, fully automatic structure solution and refinement during data collection. Developed in collaboration with OlexSys Ltd (Durham University, UK), AutoChem works in conjunction with Olex² where more advanced structure solution and refinement functionality exists. AutoChem is seamlessly integrated within CrysAlisPro, and forms an integral part of our ‘What is this?’ feature. The ‘What is this?’ feature gives you structures quickly and ensures you are not wasting time collecting full datasets on known samples or starting materials. It is an alternative pre-experiment option, which is used to plan your full data collections.

Specifications
Product name XtaLAB Synergy-DW
Core attributes Dual wavelength rotating anode X-ray source diffractometer with hybrid pixel array detector and kappa goniometer
Detectors HyPix-6000HE, the large theta coverage HyPix-Arc 150°,  or Dectris EIGER 4M
X-ray source PhotonJet-R X-ray source with a target that is constructed with two different X-ray source materials (the following combinations are available: Mo/Cu, Cu/Cr, Cu/Co, and Ag/Mo) and is coupled with an auto-switching dual-wavelength optic.
Goniometer Fast kappa geometry goniometer that allows data collection scan speeds of up to 10°/sec.
Accessories Oxford Cryostream 800, Oxford Cobra, XtalCheck-S
Computer External PC, MS Windows® OS, CrysAlisPro Software
Core dimensions 1300 (W) x 1875 (H) x 850 (D) (mm)
Mass 600 kg (core unit)
Power requirements 1Ø, 200-230 V, 20 A

Video for XtaLAB Synergy-DW diffractometer

Options and Accessories

The following accessories are available for this product
HyPix-Arc 150°

The HyPix-Arc 150° is an optional, unique curved Hybrid Photon Counting (HPC) X-ray detector for single crystal diffraction applications.

Oxford Cryostream 800

The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.

Oxford Cobra

The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.

XtalCheck

The XtalCheck system includes software that facilitates both visual and diffraction imaging of crystallization experiments. With the XtalCheck system, one can easily survey many crystallization experiments by eliminating the need to harvest and cryo-cool samples. Moreover, one can perform serial crystallography experiments, by collecting data from multiple crystals, to achieve complete data sets that can be used for structure solution.

EIDGER R 4M

The EIGER R 4M (active area: 155.2 mm x 162.5 mm, rivaling that of CCDs and imaging plate detectors) combines exceptional data collection efficiency and resolving power.

Papers published using the XtaLAB Synergy-DW

  1. Fenghua Ding, Weilong Zhang, Matthew L. Nisbet, Weiguo Zhang, P. Shiv Halasyamani, Zhihua Yang, Shilie Pan, Kenneth R. Poeppelmeier NaRb3B6O9(OH)3(HCO3): A Borate-Bicarbonate Nonlinear Optical Material Inorganic Chemistry 2020 59(1) , 759-766
  2. Günther Horrer, Mirjam J. Krahfuß, Katharina Lubitz, Ivo Krummenacher, Holger Braunschweig, Udo Radius N-Heterocyclic Carbene and Cyclic (Alkyl)(amino)carbene Complexes of Titanium(IV) and Titanium(III) Eur. J. Inorg. Chem. 2020, 281-291
  3. Toshihiro Fujiwara, Masataka Takashika, Masashi Hasegawa, Yutaka Ie, Yoshio Aso, Shinobu Aoyagi, Hiroyuki Otani, Masahiko Iyoda Small Structural Changes in the Alkyl Substituents of Macrocyclic π-Extended Thiophene Oligomers Causes a Key Effect on Their Stacking and Functional Properties ChemPlusChem 2019 84(6) , 694-703
  4. Min Feng, Bang-Heng Lyu, Ming-Hui Wang, Wei-Wei Wu, Yan-Cong Chen, Guo-Zhang Huang, Wei-Quan Lin, Si-Guo Wu, Jun-Liang Liu, Ming-Liang Tong Chiral Erbium(III) Complexes: Single-Molecule Magnet Behavior, Chirality, and Nuclearity Control Inorganic Chemistry 2019 58(16) , 10694-10703
  5. Huaiyuan Hu, Monica Vasiliu, Trent H. Stein, Fengrui Qu, Deidra L. Gerlach, David A. Dixon, Kevin H. Shaughnessy Synthesis, Structural Characterization, and Coordination Chemistry of (Trineopentylphosphine)palladium(aryl)bromide Dimer Complexes ([(Np3P)Pd(Ar)Br]2) Inorganic Chemistry 2019 58(19) , 13299-13313