Elemental / phase analysis to molecular structure
X-ray diffraction (XRD) and X-ray fluorescence (XRF) are established analytical methods in drug discovery and production quality control. From identification of active ingredient (API) via traditional remedies or by serendipitous discovery to so-called "rational drug design," Rigaku has been on the forefront in the development of single crystal diffraction instruments and software for both macromolecular and small molecule structure determination. Many aspects of discovery, design, development and formulation processes require structural information acquired by X-ray diffraction techniques. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. Rigaku offers a range of instruments and software solutions to ensure critical quality attributes (CQAs) and process parameters (CPPs) for regulated (FDA part11 compliant) and non-regulated environments. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.
Handheld Material Analysis
The Rigaku Progeny 1064 nm handheld Raman analyzer transforms material analysis for pharmaceutical companies by integrating the most versatile tool into existing workflows. Progeny utilizes 1064 nm-based Raman spectroscopy enabling accurate analysis through packaging for raw material identification (RMID), verification of finished products, or authentication for anti-counterfeit prevention.
Application Notes
The following application notes are relevant to this industrySmall Molecule, Single crystal
Raman
XRD
X-ray Imaging
Protein, Single crystal
Thermal Analysis
WDXRF
Total reflection XRF (TXRF)
EGA, Thermal Analysis
Small Molecule
XRD, Thermal Analysis
Protein
X-ray CT, Computed tomography
Rigaku recommends the following systems:
WDXRF
Benchtop tube below sequential WDXRF spectrometer analyzes O through U in solids, liquids and powders
High power, tube above, sequential WDXRF spectrometer with new ZSX Guidance expert system software
High-throughput tube-above multi-channel simultaneous WDXRF spectrometer analyzes Be through U
High-power, tube-below, sequential WDXRF spectrometer with new ZSX Guidance expert system software
Single crystal
Our most popular diffractometer for chemical crystallography, configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector.
A benchtop single crystal X-ray diffractometer ideal for self-service crystallography and teaching.
A modern single crystal X-ray diffractometer for structural analysis of small molecule samples configured with microfocus sealed tube technology and a direct X-ray detection detector.
An extremely high-flux rotating anode X-ray diffractometer specifically configured for measuring difficult samples.
A dual-wavelength, extremely high-flux, rotating anode X-ray diffractometer specifically configured for measuring difficult samples as well as providing versatility through multiple wavelengths.
A bespoke, extremely high-flux diffractometer with custom enclosure and the flexibility to utilize both ports of the rotating anode X-ray source.
A unique curved single crystal X-ray diffraction detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.
XRD
New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification
Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software
Small Molecule
User-inspired data collection and data processing software for small molecule and protein crystallography
Robotic sample changer to provide unattended data acquisition, enhanced productivity and standardized workflow to your research environment.
Protein
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
A microfocus sealed tube single crystal X-ray diffractometer that is low maintenance and perfect for screening and evaluating protein crystals.
A single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator and direct detection, HPC X-ray detector.
A versatile and high-flux dual-wavelength (DW) X-ray diffractometer with an HPC X-ray detector for multipurpose diffraction experiments
Thermal Analysis
TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).
Detectors
2D X-ray detector with latest semiconductor technology designed for home lab diffractometers
A unique curved single crystal X-ray diffraction detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.