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Pharmaceuticals

Pharmaceuticals

Elemental / phase analysis to molecular structure

X-ray diffraction (XRD) and X-ray fluorescence (XRF) are established analytical methods in drug discovery and production quality control. From identification of active ingredient (API) via traditional remedies or by serendipitous discovery to so-called "rational drug design," Rigaku has been on the forefront in the development of single crystal diffraction instruments and software for both macromolecular and small molecule structure determination. Many aspects of discovery, design, development and formulation processes require structural information acquired by X-ray diffraction techniques. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. Rigaku offers a range of instruments and software solutions to ensure critical quality attributes (CQAs) and process parameters (CPPs) for regulated (FDA part11 compliant) and non-regulated environments. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.

Handheld Material Analysis

The Rigaku Progeny 1064 nm handheld Raman analyzer transforms material analysis for pharmaceutical companies by integrating the most versatile tool into existing workflows. Progeny utilizes 1064 nm-based Raman spectroscopy enabling accurate analysis through packaging for raw material identification (RMID), verification of finished products, or authentication for anti-counterfeit prevention.
 

Rigaku recommends the following systems:


Single crystal

Our most popular diffractometer for chemical crystallography, configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector.

A benchtop single crystal X-ray diffractometer ideal for self-service crystallography and teaching.

A modern single crystal X-ray diffractometer for structural analysis of small molecule samples configured with microfocus sealed tube technology and a direct X-ray detection detector.

An extremely high-flux rotating anode X-ray diffractometer specifically configured for measuring difficult samples.

A dual-wavelength, extremely high-flux, rotating anode X-ray diffractometer specifically configured for measuring difficult samples as well as providing versatility through multiple wavelengths.

A bespoke, extremely high-flux diffractometer with custom enclosure and the flexibility to utilize both ports of the rotating anode X-ray source.

A unique curved single crystal X-ray diffraction detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.

XRD

New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

Small Molecule

User-inspired data collection and data processing software for small molecule and protein crystallography

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Protein

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Automated crystal transport, orientation and retrieval robot

A microfocus sealed tube single crystal X-ray diffractometer that is low maintenance and perfect for screening and evaluating protein crystals.

A single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator and direct detection, HPC X-ray detector.

A versatile and high-flux dual-wavelength (DW) X-ray diffractometer with an HPC X-ray detector for multipurpose diffraction experiments

SAXS

Small angle X-ray scattering (SAXS) Kratky camera system

Thermal Analysis

TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).

 

 

Detectors

2D X-ray detector with latest semiconductor technology designed for home lab diffractometers

A unique curved single crystal X-ray diffraction detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.

WDXRF

High-power, tube-below, sequential WDXRF spectrometer with new ZSX Guidance expert system software

Applications

The following applications are relevant to this industry

Raman

Small Molecule, Single crystal

Protein, Single crystal

XRD

X-ray Imaging

Thermal Analysis

XRD, Thermal Analysis

WDXRF

Total reflection XRF (TXRF)

EGA, Thermal Analysis

SAXS, Protein, Single crystal

Small Molecule

Protein

Protein, Single crystal, Optics