Recognizing the potential of MicroED, Rigaku and JEOL announced a collaboration in 2020 to develop a new product designed in a fashion that will make it easy for any crystallographer to use. The resulting product is the XtaLAB Synergy-ED, Figure 1, a new and fully integrated electron diffractometer, that creates a seamless workflow from data collection to structure determination of three-dimensional molecular structures. The XtaLAB Synergy-ED combines core technologies from the two companies: Rigaku’s high-speed, highsensitivity detector (HyPix-ED), and instrument control and single crystal analysis software platform (CrysAlisPro ED), and JEOL’s expertise in generation and control of stable electron beams. There are many materials that only form nanosized crystals. Before the development of the MicroED technique, synthetic chemists were forced to rely on other techniques, such as NMR, to postulate 3D structure. Unfortunately, for complicated molecules such as natural products, the NMR results can be difficult to interpret. MicroED has thus become a revolutionary technique for the advancement of structural science.