蛋白质/生物大分子晶体学

用于合理药物设计的大分子三维结构

蛋白质/生物大分子晶体学该技术采用单晶X射线衍射(SXRD),明确地确定了大生物分子的三维结构。医药和生物技术研究人员需要了解如何在蛋白质和相关大分子内的分子水平上控制疾病,因此基于这种知识确定特定实体目标。这种方法的前提是根据调查,获得大分子的高分辨率分子三维结构。鉴于此研究的重要性,理学公司一直站在与生物大分子学各个方面相关的广泛的仪器仪表发展的最前沿。

仪器

X-ray Diffraction systems
 
Synergy-R   XtaLAB Synergy-R
Single crystal X-ray diffractometer with MicroMax-007 HF microfocus rotating anode X-ray generator
  Synergy-S   XtaLAB Synergy-S
Fast, flexible single crystal X-ray diffractometer with the latest generation microfocus sources and HPC X-ray detectors, perfect for any crystallography lab.
 
Synergy Custom   XtaLAB Synergy Custom
Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components
   

SAXS systems 
 
BioSAXS-2000   BioSAXS-2000
Small angle X-ray scattering (SAXS) Kratky camera system
       
In Situ Crystallography 
 
PX Scanner   PX Scanner
Imaging and X-ray diffraction collection for crystals directly from crystallization plates
  PlateMate   PlateMate
Goniometer adapter for X-ray diffraction screening of samples in crystallization plates
  XtalCheck   XtalCheck
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
Reagents
 
Rigaku Reagents   Rigaku Reagents
Reagent kits, stock solutions, and accessories for
protein crystallography researchers
 

 

 

 Detectors 
 
HyPix-6000HE detector HyPix-6000HE detector
Hybrid Photon Counting (HPC) detector offering direct X-ray photon counting, single pixel point spread function and extremely low noise
PILATUS3 R detectors PILATUS3 R detectors
PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography
 Automatic Sample Changer 
 
ACTOR   ACTOR sample changer
Automated crystal transport, orientation and retrieval robot

Protein X-ray crystallography is a powerful structural biology technique that provides atomic resolution details about proteins and other macromolecular molecules involved in all aspects of life and disease. Rigaku is a world leader in providing instrumentation that can improve productivity at many levels — from making crystallization solutions and growing crystals to automatically mounting crystals and collecting high resolution single crystal X-ray diffraction data sets. Please select a system or component of interest to find out how Rigaku can assist you in your protein crystallography research.