Elemental / phase analysis to molecular structure
X-ray diffraction (XRD) and X-ray fluorescence (XRF) are established analytical methods in drug discovery and production quality control. From identification of active ingredient (API) via traditional remedies or by serendipitous discovery to so-called "rational drug design," Rigaku has been on the forefront in the development of single crystal diffraction instruments and software for both macromolecular and small molecule structure determination. Many aspects of discovery, design, development and formulation processes require structural information acquired by X-ray diffraction techniques. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. Rigaku offers a range of instruments and software solutions to ensure critical quality attributes (CQAs) and process parameters (CPPs) for regulated (FDA part11 compliant) and non-regulated environments. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.
Handheld Material Analysis
The Rigaku Progeny 1064 nm handheld Raman analyzer transforms material analysis for pharmaceutical companies by integrating the most versatile tool into existing workflows. Progeny utilizes 1064 nm-based Raman spectroscopy enabling accurate analysis through packaging for raw material identification (RMID), verification of finished products, or authentication for anti-counterfeit prevention.
Application Notes
The following application notes are relevant to this industrySmall Molecule, Single crystal
Raman
XRD
X-ray Imaging
Protein, Single crystal
Thermal Analysis
WDXRF
Total reflection XRF (TXRF)
EGA, Thermal Analysis
Small Molecule
XRD, Thermal Analysis
Protein
X-ray CT, Computed tomography
Rigaku recommends the following systems:
WDXRF
Sequentielles WDRFA Spektrometer zur Analyse der Elemente von O bis U in Feststoffen, Flüssigkeiten und Pulvern
Sequenzielles WDRFA-Spektrometer mit hoher Leistung, Röhre oberhalb der Probe, mit ZSX Guidance Systemsoftware
High-throughput tube below multi-channel simultaneous WDXRF spectrometer analyzes Be through U
High-power, tube-below, sequential WDXRF spectrometer with new ZSX Guidance expert system software
Single crystal
Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab
A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.
An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples
Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator
Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments
Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components
XRD
New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification
High-performance, multi-purpose XRD system for applications ranging from R&D to quality control
Raman
Handheld Raman for raw material identification and finished product authentication using 1064 nm Raman analysis.
Small Molecule
User-inspired data collection and data processing software for small molecule and protein crystallography
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
Protein
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab
Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator
Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments
EDXRF
Performance EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin-films
High-performance, Cartesian-geometry EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin films
Detectors
2D X-ray detector with latest semiconductor technology designed for home lab diffractometers
X-ray CT
Thermal Analysis
TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).