Skip to main content

Quantitative analysis of crystal polymorphs by the DD method

AppNote B-XRD1142: Quantitative analysis of crystal polymorphs by the DD method


In the Direct Derivation (DD) method, quantitative analysis is performed using the sum of the X-ray intensities scattered from each crystalline phase and the chemical composition information. In some fields, such as pharmaceuticals, many compounds are not listed in databases. In these cases, it is difficult to calculate quantitative values using conventional methods, and thus quantitative analysis using the DD method is considered effective. In this example, each crystalline phase of a compound having different polymorphic forms was measured, and then quantitative analysis of a mixture using the results from the pure forms was performed.

XRD products from Rigaku

Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

High-performance, multi-purpose XRD system for applications ranging from R&D to quality control

Windows®-based software suite for Rigaku's X-ray diffractometers

Laboratory micro-spot XRD residual stress analysis with both iso- and side-inclination methods

2D X-ray detector with latest semiconductor technology designed for home lab diffractometers