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Pharmaceuticals

Pharmaceuticals

Elemental / phase analysis to molecular structure

X-ray diffraction (XRD) and X-ray fluorescence (XRF) are established analytical methods in drug discovery and production quality control. From identification of active ingredient (API) via traditional remedies or by serendipitous discovery to so-called "rational drug design," Rigaku has been on the forefront in the development of single crystal diffraction instruments and software for both macromolecular and small molecule structure determination. Many aspects of discovery, design, development and formulation processes require structural information acquired by X-ray diffraction techniques. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. Rigaku offers a range of instruments and software solutions to ensure critical quality attributes (CQAs) and process parameters (CPPs) for regulated (FDA part11 compliant) and non-regulated environments. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.

Handheld Material Analysis

The Rigaku Progeny 1064 nm handheld Raman analyzer transforms material analysis for pharmaceutical companies by integrating the most versatile tool into existing workflows. Progeny utilizes 1064 nm-based Raman spectroscopy enabling accurate analysis through packaging for raw material identification (RMID), verification of finished products, or authentication for anti-counterfeit prevention.
 

Rigaku recommends the following systems:


WDXRF

Sequentielles WDRFA Spektrometer zur Analyse der Elemente von O bis U in Feststoffen, Flüssigkeiten und Pulvern

High power, tube below, sequential WDXRF spectrometer with Smart Sample Loading System (SSLS)

Sequenzielles WDRFA-Spektrometer mit hoher Leistung, Röhre oberhalb der Probe, mit ZSX Guidance Systemsoftware

High power, tube above, sequential WDXRF spectrometer

WDXRF spectrometer designed to handle very large and/or heavy samples

High-throughput tube below multi-channel simultaneous WDXRF spectrometer analyzes Be through U

Tube below, single element WDXRF analyzer for quality control applications

High-power, tube-below, sequential WDXRF spectrometer with new ZSX Guidance expert system software

Single crystal

Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab

A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.

An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples

Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components

A unique curved single crystal X-ray diffraction detector

XRD

New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

High-performance, multi-purpose XRD system for applications ranging from R&D to quality control

Raman

Handheld Raman for raw material identification and finished product authentication using 1064 nm Raman analysis.

Small Molecule

User-inspired data collection and data processing software for small molecule and protein crystallography

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Protein

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Automated crystal transport, orientation and retrieval robot

Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab

Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

EDXRF

Performance EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin-films

New variable collimator small spot 60 kV EDXRF system featuring QuantEZ software.

EDXRF spectrometer with powerful Windows® software and optional FP.

High-performance, Cartesian-geometry EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin films

Detectors

PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography

2D X-ray detector with latest semiconductor technology designed for home lab diffractometers

Compact, highly sensitive X-ray detector for single crystal applications

A unique curved single crystal X-ray diffraction detector

SAXS

Small angle X-ray scattering (SAXS) Kratky camera system

X-ray CT

Ultra-high resolution nanotomography using parallel beam geometry

High-resolution benchtop microtomography of large samples

Thermal Analysis

TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).

 

 

Applications

The following applications are relevant to this industry

Raman

Small Molecule, Single crystal

Protein, Single crystal

XRD

X-ray Imaging

Thermal Analysis

XRD, Thermal Analysis

WDXRF

Total reflection XRF (TXRF)

EGA, Thermal Analysis

SAXS, Protein, Single crystal

Small Molecule

Protein

Protein, Single crystal, Optics