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Pharmaceuticals

Pharmaceuticals

Elemental / phase analysis to molecular structure

In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and designed. In the recent past, most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach, using so-called "rational drug design", has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge. Given this importance, Rigaku has been at the forefront in the development of single crystal diffraction for both macromolecular and small molecule structure determination. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.

X-ray powder diffraction is extensively used in the drug discovery, design, development and formulation processes to obtain critical knowledge about pharmaceutical products. Many parameters required by the FDA, legal patent issues and drug performance are only accessible by employing XRD. With the introduction of systems specifically developed with the pharmaceutical industry in mind, XRD is now both cost-effective and easy-to-use. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. In addition, crystal structure determination, the study of non-ambient behavior, and overall morphology help to provide a complete understanding of the properties of a pharmaceutical agent.

Rigaku recommends the following systems:


WDXRF

Sequentielles WDRFA Spektrometer zur Analyse der Elemente von O bis U in Feststoffen, Flüssigkeiten und Pulvern

High power, tube below, sequential WDXRF spectrometer with Smart Sample Loading System (SSLS)

Sequenzielles WDRFA-Spektrometer mit hoher Leistung, Röhre oberhalb der Probe, mit ZSX Guidance Systemsoftware

High power, tube above, sequential WDXRF spectrometer

WDXRF spectrometer designed to handle very large and/or heavy samples

High-throughput tube below multi-channel simultaneous WDXRF spectrometer analyzes Be through U

Tube below, single element WDXRF analyzer for quality control applications

Small Molecule

Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab

A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.

An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples

Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

User-inspired data collection and data processing software for small molecule and protein crystallography

Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components

XRD

New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

High-performance, multi-purpose XRD system for applications ranging from R&D to quality control

Raman

Handheld Raman for raw material identification and finished product authentication using 1064 nm Raman analysis.

Protein

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Automated crystal transport, orientation and retrieval robot

Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components

Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab

Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

Automated crystal transport, orientation and retrieval robot

EDXRF

Performance EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin-films

New variable collimator small spot 60 kV EDXRF system featuring QuantEZ software.

EDXRF spectrometer with powerful Windows® software and optional FP.

High-performance, Cartesian-geometry EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin films

Detectors

PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography

2D X-ray detector with latest semiconductor technology designed for home lab diffractometers

Compact, highly sensitive X-ray detector for single crystal applications

A unique curved single crystal X-ray diffraction detector

SAXS

Small angle X-ray scattering (SAXS) Kratky camera system

X-ray CT

Ultra-high resolution nanotomography using parallel beam geometry

High-resolution benchtop microtomography of large samples

Thermal Analysis

TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).

 

 

Applications

The following applications are relevant to this industry

Raman

Protein

Small Molecule

SAXS, Protein

XRD

X-ray Imaging

Thermal Analysis

XRD, Thermal Analysis

WDXRF

Total reflection XRF (TXRF)

EGA, Thermal Analysis